The role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors

Kevin Boyé; Nadège Pujol; Isabel D Alves; Ya-Ping Chen; Thomas Daubon; Yi-Zong Lee; Stephane Dedieu; Marion Constantin; Lorenzo Bello; Marco Rossi; Rolf Bjerkvig; Shih-Che Sue; Andreas Bikfalvi; Clotilde Billottet

doi:10.1038/s41467-017-01686-y

Nature Communications (Nov 2017)

The role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors

Kevin Boyé,
Nadège Pujol,
Isabel D Alves,
Ya-Ping Chen,
Thomas Daubon,
Yi-Zong Lee,
Stephane Dedieu,
Marion Constantin,
Lorenzo Bello,
Marco Rossi,
Rolf Bjerkvig,
Shih-Che Sue,
Andreas Bikfalvi,
Clotilde Billottet

Affiliations

Kevin Boyé: INSERM U1029
Nadège Pujol: INSERM U1029
Isabel D Alves: CBMN
Ya-Ping Chen: Institute of Bioinformatics and Structural Biology, NTHU
Thomas Daubon: INSERM U1029
Yi-Zong Lee: Institute of Bioinformatics and Structural Biology, NTHU
Stephane Dedieu: CNRS UMR 7369 MEDyC, Université de Reims Champagne-Ardenne
Marion Constantin: INSERM U1029
Lorenzo Bello: Neurosurgical Oncology Unit, Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Humanitas Resarch Hospital
Marco Rossi: Neurosurgical Oncology Unit, Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Humanitas Resarch Hospital
Rolf Bjerkvig: K.G. Jebsen Brain Tumour Research Centre, Department of Biomedicine, University of Bergen
Shih-Che Sue: Institute of Bioinformatics and Structural Biology, NTHU
Andreas Bikfalvi: INSERM U1029
Clotilde Billottet: INSERM U1029

DOI: https://doi.org/10.1038/s41467-017-01686-y
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 20

Abstract

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The chemokine receptor CXCR3-A is expressed in high grade glioma. Here the authors show that CXCR3-A interacts with LPR1, a protein highly expressed in glioma, and this interaction regulates the trafficking of the receptor ultimately impacting on tumour cell migration.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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