Biologics: Targets & Therapy (Feb 2022)

A Non-Interventional Multicenter Study of First-Line Bevacizumab in Combination with Chemotherapy in Patients with Metastatic Colorectal Cancer in Lebanon

  • Temraz S,
  • Nasr F,
  • Kattan J,
  • Abigerges D,
  • Moukadem W,
  • Farhat F,
  • Maatouk L,
  • Chahine G,
  • Shamseddine A

Journal volume & issue
Vol. Volume 16
pp. 7 – 15

Abstract

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Sally Temraz,1 Fadi Nasr,2 Joseph Kattan,3 Dany Abigerges,4 Walid Moukadem,5 Fadi Farhat,6 Layal Maatouk,7 Georges Chahine,8 Ali Shamseddine1 1Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon; 2Department of Hematology and Oncology, Mount Lebanon Hospital, Beirut, Lebanon; 3Department of Hematology and Oncology, Saint- Joseph University, Beirut, Lebanon; 4Department of Hematology and Oncology, Middle East Institute of Health, Bsalim, Lebanon; 5Department of Hematology and Oncology, Haykal Hospital, Tripoli, Lebanon; 6Department of Hematology and Oncology, Hammoud Hospital University Medical Center, Saida, Lebanon; 7Roche Lebanon SARL, Beirut, Lebanon; 8Department of Hematology and Oncology, Hôtel-Dieu de France University Hospital, Beirut, LebanonCorrespondence: Ali Shamseddine, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon, Tel +961 1 374374, Fax +961 1 370814, Email [email protected]: When combined with chemotherapy, bevacizumab improves progression-free survival (PFS) in metastatic colorectal cancer (mCRC). This observational trial was designed to assess the safety and efficacy of bevacizumab plus first-line chemotherapy in a real-world setting in Lebanon.Patients and Methods: A non-interventionaL multicenter study of first-LIne AVastin® (bevacizumab) in combination with chEmotherapy in patients with metastatic colorectal cancer (LLIVE) is a multicenter, prospective, Lebanon-based, observational study that enrolled mCRC patients who received first-line bevacizumab plus chemotherapy combination. The primary end point of the study was PFS. Secondary endpoints comprised the overall response rate (ORR) and the safety and tolerability of bevacizumab.Results: A total of 196 patients were enrolled between July 2010 and August 2013. The median duration of follow-up was 11 months. Median duration of bevacizumab treatment was 4 months with FOLFOX being the chiefly chemotherapy regimen used in the first-line setting (26%). Median PFS was 8.22 months (95% confidence interval (CI): 7.005– 9.443). The ORR was 50.3% (complete response 7.5%, partial response 42.8%). The most common adverse event encountered was hypertension (28%) followed by epistaxis (4.8%), diarrhea (4%), anemia (4%) and headache (4%). Grade 3/4 adverse events occurred in 15.2% of patients.Conclusion: The trial further substantiated the efficacy and safety of bevacizumab and chemotherapy in the first-line treatment of mCRC patients in Lebanon.Keywords: metastatic colorectal cancer, bevacizumab, FOLFOX, XELOX

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