Nature Communications (Nov 2017)

Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1

  • Ariel Lewis-Ballester,
  • Khoa N. Pham,
  • Dipanwita Batabyal,
  • Shay Karkashon,
  • Jeffrey B. Bonanno,
  • Thomas L. Poulos,
  • Syun-Ru Yeh

DOI
https://doi.org/10.1038/s41467-017-01725-8
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 8

Abstract

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Human indoleamine 2,3-dioxygenase 1 (hIDO1) is an immunotherapeutic target for cancer therapy. Here, the authors present the substrate-, inhibitor- and effector-bound hIDO1 crystal structures, which give insights into the mechanism and reveal a second small molecule binding site, which is of interest for drug design.