Nature Communications (Apr 2019)
Rbpj expression in regulatory T cells is critical for restraining TH2 responses
- Michael Delacher,
- Christian Schmidl,
- Yonatan Herzig,
- Minka Breloer,
- Wiebke Hartmann,
- Fabian Brunk,
- Danny Kägebein,
- Ulrike Träger,
- Ann-Cathrin Hofer,
- Sebastian Bittner,
- Dieter Weichenhan,
- Charles D. Imbusch,
- Agnes Hotz-Wagenblatt,
- Thomas Hielscher,
- Achim Breiling,
- Giuseppina Federico,
- Hermann-Josef Gröne,
- Roland M. Schmid,
- Michael Rehli,
- Jakub Abramson,
- Markus Feuerer
Affiliations
- Michael Delacher
- Chair for Immunology, University Regensburg and University Hospital Regensburg
- Christian Schmidl
- Regensburg Center for Interventional Immunology (RCI), University Regensburg and University Hospital Regensburg
- Yonatan Herzig
- Department of Immunology, Weizmann Institute of Science
- Minka Breloer
- Bernhard Nocht Institute for Tropical Medicine
- Wiebke Hartmann
- Bernhard Nocht Institute for Tropical Medicine
- Fabian Brunk
- Division of Developmental Immunology, German Cancer Research Center (DKFZ)
- Danny Kägebein
- Immune Tolerance Group, Tumor Immunology Program, German Cancer Research Center (DKFZ)
- Ulrike Träger
- Immune Tolerance Group, Tumor Immunology Program, German Cancer Research Center (DKFZ)
- Ann-Cathrin Hofer
- Immune Tolerance Group, Tumor Immunology Program, German Cancer Research Center (DKFZ)
- Sebastian Bittner
- Chair for Immunology, University Regensburg and University Hospital Regensburg
- Dieter Weichenhan
- Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ)
- Charles D. Imbusch
- Division of Applied Bioinformatics, German Cancer Research Center (DKFZ)
- Agnes Hotz-Wagenblatt
- Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ)
- Thomas Hielscher
- Division of Biostatistics, German Cancer Research Center (DKFZ)
- Achim Breiling
- Division of Epigenetics, German Cancer Research Center (DKFZ)
- Giuseppina Federico
- Division of Cellular and Molecular Pathology, German Cancer Research Center (DKFZ)
- Hermann-Josef Gröne
- Division of Cellular and Molecular Pathology, German Cancer Research Center (DKFZ)
- Roland M. Schmid
- Department of Internal Medicine, Technical University of Munich
- Michael Rehli
- Regensburg Center for Interventional Immunology (RCI), University Regensburg and University Hospital Regensburg
- Jakub Abramson
- Department of Immunology, Weizmann Institute of Science
- Markus Feuerer
- Chair for Immunology, University Regensburg and University Hospital Regensburg
- DOI
- https://doi.org/10.1038/s41467-019-09276-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 20
Abstract
Transcriptional regulator Rbpj is involved in T-helper subset differentiation. Here the authors show that expression of Rbpj in regulatory T cells is required to both regulate TH2 responses and regulate Treg TH2 differentiation potential.
