Peroxisome inspired hybrid enzyme nanogels for chemodynamic and photodynamic therapy

Xing Qin; Chu Wu; Dechao Niu; Limei Qin; Xia Wang; Qigang Wang; Yongsheng Li

doi:10.1038/s41467-021-25561-z

Nature Communications (Sep 2021)

Peroxisome inspired hybrid enzyme nanogels for chemodynamic and photodynamic therapy

Xing Qin,
Chu Wu,
Dechao Niu,
Limei Qin,
Xia Wang,
Qigang Wang,
Yongsheng Li

Affiliations

Xing Qin: Lab of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, Frontier Science Center of the Materials Biology and Dynamic Chemistry, School of Materials Science and Engineering, East China University of Science and Technology
Chu Wu: School of Chemical Science and Engineering, Tongji University
Dechao Niu: Lab of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, Frontier Science Center of the Materials Biology and Dynamic Chemistry, School of Materials Science and Engineering, East China University of Science and Technology
Limei Qin: Lab of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, Frontier Science Center of the Materials Biology and Dynamic Chemistry, School of Materials Science and Engineering, East China University of Science and Technology
Xia Wang: School of Chemical Science and Engineering, Tongji University
Qigang Wang: School of Chemical Science and Engineering, Tongji University
Yongsheng Li: Lab of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, Frontier Science Center of the Materials Biology and Dynamic Chemistry, School of Materials Science and Engineering, East China University of Science and Technology

DOI: https://doi.org/10.1038/s41467-021-25561-z
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

Read online

The control of reactive oxygen species in cancer cells is an attractive approach for anticancer applications. Here, the authors create a peroxisome inspired lactate oxidase and catalase loaded hydrogel with iron nanoparticles and NIR photosensitizer for glutathione activated chemodynamic and photodynamic therapy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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