Spontaneous regression of metastatic clear cell renal cell carcinoma: A report of a rare case and a review of the literature

Anoushka Mullasseril; Anh B. Lam; Alekhya Mitta; Daniel Morton; Andrew McIntosh; Sanjay Patel; Theresa Thai; Anand Annan; Adanma Ayanambakkam

Urology Case Reports (Nov 2024)

Spontaneous regression of metastatic clear cell renal cell carcinoma: A report of a rare case and a review of the literature

Anoushka Mullasseril,
Anh B. Lam,
Alekhya Mitta,
Daniel Morton,
Andrew McIntosh,
Sanjay Patel,
Theresa Thai,
Anand Annan,
Adanma Ayanambakkam

Affiliations

Anoushka Mullasseril: Department of Internal Medicine, University of Oklahoma Health Sciences, Oklahoma City, OK, USA
Anh B. Lam: Department of Internal Medicine, University of Oklahoma Health Sciences, Oklahoma City, OK, USA
Alekhya Mitta: Department of Radiation Oncology, University of Oklahoma Health Sciences, Oklahoma City, OK, USA
Daniel Morton: Department of Pediatrics, University of Oklahoma Health Sciences, Oklahoma City, OK, USA; Stephenson Cancer Center, University of Oklahoma Health Sciences, Oklahoma City, OK, USA
Andrew McIntosh: Stephenson Cancer Center, University of Oklahoma Health Sciences, Oklahoma City, OK, USA; Department of Urology, University of Oklahoma Health Sciences, Oklahoma City, OK, USA
Sanjay Patel: Stephenson Cancer Center, University of Oklahoma Health Sciences, Oklahoma City, OK, USA; Department of Urology, University of Oklahoma Health Sciences, Oklahoma City, OK, USA
Theresa Thai: Stephenson Cancer Center, University of Oklahoma Health Sciences, Oklahoma City, OK, USA; Department of Radiological Sciences, University of Oklahoma Health Sciences, Oklahoma City, OK, USA
Anand Annan: Department of Pathology, University of Oklahoma Health Sciences, Oklahoma City, OK, USA
Adanma Ayanambakkam: Stephenson Cancer Center, University of Oklahoma Health Sciences, Oklahoma City, OK, USA; Department of Internal Medicine, Division of Hematology & Oncology, University of Oklahoma Health Sciences, Oklahoma City, USA; Corresponding author. Division of Hematology & Medical Oncology Stephenson Cancer Center, 800 NE 10th St, Oklahoma City, OK, 73104, USA.

Journal volume & issue: Vol. 57
p. 102868

Abstract

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Renal cell carcinoma (RCC) is the seventh most common cancer in the United States; clear cell RCC (ccRCC) is the most common subtype. We report a case of spontaneous regression of metastatic ccRCC and discuss possible underlying mechanisms informed by a literature review. While regression of metastatic RCC has been described following nephrectomy or treatment of the primary tumor, spontaneous regression is rare. Postulated underlying causes include tumor necrosis and immune-mediated responses. Of 29 identified cases of spontaneous regression, only ours occurred after only a biopsy. Better understanding of the pathophysiology of spontaneous regression in RCC will improve its management.

Published in Urology Case Reports

ISSN: 2214-4420 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the genitourinary system. Urology
Website: http://www.urologycasereports.com/

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