Use of Intralesional and Perilesional Human Recombinant Epidermal Growth Factor (hrEGF) in the Local Treatment of Venous Ulcer – Review Article – Expert Recommendation

Abstract

Maria Teresa Cacua Sanchez,1 Lina M Vargas Abello,2 Álvaro Orrego,3 Paola Ortiz,4 Héctor Segura,5 Jhon Jairo Berrio Caicedo,6 Luz Marina Zuluaga,7 José Ordoñez,8 José Ignacio Fernández Montequin,9 Jorge Ulloa10 1Ambulatory Surgery Center, Kennedy Hospital, Vascular Laboratory SURA, Bogotá, Colombia; 2Lumina Vein & Aesthetic Institute, Windermere, FL, USA; 3Laser & Veins Clinic, Viña del Mar, Chile; 4Uruguay Vein Center, Universidad de la República Oriental de Uruguay, Montevideo, Uruguay; 5Vascular and Endovascular Surgery Department, Hospital Español, Mexico City, Mexico; 6Universidad Del Valle, San José de Buga Hospital Foundation, Buga, Colombia; 7San Juan de Dios Hospital, Cartago Valle, Colombia; 8Department of Vascular Surgery, Fundación Santa Fe, Bogotá, Colombia; 9National Institute of Angiology and Vascular Surgery, Havana, Cuba; 10Department of Vascular Surgery, Fundación Santa Fe de Bogotá, Universidad de los Andes, Bogota, ColombiaCorrespondence: Maria Teresa Cacua Sanchez, Email [email protected]: Venous Ulcers (VU) represent 60– 80% of all leg ulcers and are the final stage of the disease secondary to venous hypertension or valve insufficiency. Conventional treatment that focuses on its etiological factors continues to be the gold standard; however, 30% of ulcers do not heal with this treatment; thus, it has been seen that the use of growth factor can be used as an adjuvant for this pathology. A literature review was carried out to evaluate the evidence from systematic reviews, meta-analyses, case studies, and quantitative studies that respond to the objective of this analysis review in the different databases with specific inclusion criteria with publications between 2002 and 2022, initially finding the topical application of the factor and later, more recently, the intralesional and perilesional application, the latter being an alternative treatment for this type of pathology and generating some recommendations for using the Factor.Keywords: chronic venous fibroblast dysfunctions, recombinant human epidermal growth factor, rhEGF, intralesional, perilesional, fibroblast dysfunctions

Keywords

• chronic venous fibroblast dysfunctions
• recombinant human epidermal growth factor
• rhegf
• intralesional
• perilesional
• fibroblast dysfunctions.