Communications Biology (Jan 2021)

Multimodal in vivo recording using transparent graphene microelectrodes illuminates spatiotemporal seizure dynamics at the microscale

  • Nicolette Driscoll,
  • Richard E. Rosch,
  • Brendan B. Murphy,
  • Arian Ashourvan,
  • Ramya Vishnubhotla,
  • Olivia O. Dickens,
  • A. T. Charlie Johnson,
  • Kathryn A. Davis,
  • Brian Litt,
  • Danielle S. Bassett,
  • Hajime Takano,
  • Flavia Vitale

DOI
https://doi.org/10.1038/s42003-021-01670-9
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 14

Abstract

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Driscoll, Rosch et al. design transparent graphene-based surface probes to achieve simultaneous electrophysiological recording and calcium imaging of epileptic seizures in mice. This method could be used to investigate circuit dynamics during seizure onset and evolution with high temporal and spatial resolution.