Alterations of the plasma lipoproteins and apoproteins following cholesterol feeding in the rat

Abstract

The feeding of cholesterol to rats resulted in marked alterations in the type and distribution of the plasma lipoproteins and their apoproteins. The hyperlipoproteinemia was characterized by an increase in the d 1.21 fraction. Significant alterations in the arginine-rich apoprotein quantitation notwithstanding, the observations of increased arginine-rich apoprotein in the B-VLDL, intermediate fraction, and HDLc following cholesterol feeding remained valid. However, precise quantitation awaits refinements in lipoprotein isolation techniques.

Keywords

• Two-dimensional quantitative immunoelectrophoresis
• arginine-rich apoprotein
• atherogenic hypercholesterolemia