Cryoprotectant enables structural control of porous scaffolds for exploration of cellular mechano-responsiveness in 3D

Shumeng Jiang; Cheng Lyu; Peng Zhao; Wenjing Li; Wenyu Kong; Chenyu Huang; Guy M. Genin; Yanan Du

doi:10.1038/s41467-019-11397-1

Nature Communications (Aug 2019)

Cryoprotectant enables structural control of porous scaffolds for exploration of cellular mechano-responsiveness in 3D

Shumeng Jiang,
Cheng Lyu,
Peng Zhao,
Wenjing Li,
Wenyu Kong,
Chenyu Huang,
Guy M. Genin,
Yanan Du

Affiliations

Shumeng Jiang: Department of Biomedical Engineering, School of Medicine, Tsinghua-Peking Center for Life Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Tsinghua University
Cheng Lyu: Department of Biomedical Engineering, School of Medicine, Tsinghua-Peking Center for Life Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Tsinghua University
Peng Zhao: Department of Biomedical Engineering, School of Medicine, Tsinghua-Peking Center for Life Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Tsinghua University
Wenjing Li: Department of Biomedical Engineering, School of Medicine, Tsinghua-Peking Center for Life Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Tsinghua University
Wenyu Kong: Department of Biomedical Engineering, School of Medicine, Tsinghua-Peking Center for Life Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Tsinghua University
Chenyu Huang: Department of Dermatology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University
Guy M. Genin: Department of Mechanical engineering and Material Science, Washington University at St. Louis
Yanan Du: Department of Biomedical Engineering, School of Medicine, Tsinghua-Peking Center for Life Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Tsinghua University

DOI: https://doi.org/10.1038/s41467-019-11397-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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Cellular responses to mechanical stimulation have emerged as an important area of research. Here, the authors use cryoprotectant to control the pore size and mechanical properties of porous scaffolds without changing the scaffold composition to allow for the study of cellular mechano-responsiveness in 3D.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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