Nature Communications (Dec 2021)
GP73 is a TBC-domain Rab GTPase-activating protein contributing to the pathogenesis of non-alcoholic fatty liver disease without obesity
- Yumeng Peng,
- Qiang Zeng,
- Luming Wan,
- Enhao Ma,
- Huilong Li,
- Xiaopan Yang,
- Yanhong Zhang,
- Linfei Huang,
- Haotian Lin,
- Jiangyue Feng,
- Yixin Xu,
- Jingfei Li,
- Muyi Liu,
- Jing Liu,
- Changqin Lin,
- Zhiwei Sun,
- Gong Cheng,
- Xuemiao Zhang,
- Jialong Liu,
- Dongrui Li,
- Meng Wei,
- Yunhai Mo,
- Xuetao Mu,
- Xiaowei Deng,
- Dandan Zhang,
- Siqing Dong,
- Hanqing Huang,
- Yi Fang,
- Qi Gao,
- Xiaoli Yang,
- Feixiang Wu,
- Hui Zhong,
- Congwen Wei
Affiliations
- Yumeng Peng
- Beijing Institute of Biotechnology, Academy of Military Medical Sciences (AMMS)
- Qiang Zeng
- Health management Institute, The Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital
- Luming Wan
- Beijing Institute of Biotechnology, Academy of Military Medical Sciences (AMMS)
- Enhao Ma
- Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University
- Huilong Li
- Beijing Institute of Biotechnology, Academy of Military Medical Sciences (AMMS)
- Xiaopan Yang
- Beijing Institute of Biotechnology, Academy of Military Medical Sciences (AMMS)
- Yanhong Zhang
- Beijing Institute of Biotechnology, Academy of Military Medical Sciences (AMMS)
- Linfei Huang
- Beijing Institute of Biotechnology, Academy of Military Medical Sciences (AMMS)
- Haotian Lin
- Beijing Institute of Biotechnology, Academy of Military Medical Sciences (AMMS)
- Jiangyue Feng
- Beijing Institute of Biotechnology, Academy of Military Medical Sciences (AMMS)
- Yixin Xu
- Beijing Institute of Biotechnology, Academy of Military Medical Sciences (AMMS)
- Jingfei Li
- Beijing Institute of Biotechnology, Academy of Military Medical Sciences (AMMS)
- Muyi Liu
- Beijing Institute of Biotechnology, Academy of Military Medical Sciences (AMMS)
- Jing Liu
- Beijing Institute of Biotechnology, Academy of Military Medical Sciences (AMMS)
- Changqin Lin
- Beijing Sungen Biomedical Technology Co., Ltd.
- Zhiwei Sun
- Beijing Sungen Biomedical Technology Co., Ltd.
- Gong Cheng
- Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University
- Xuemiao Zhang
- Beijing Institute of Biotechnology, Academy of Military Medical Sciences (AMMS)
- Jialong Liu
- Beijing Institute of Biotechnology, Academy of Military Medical Sciences (AMMS)
- Dongrui Li
- Beijing Institute of Biotechnology, Academy of Military Medical Sciences (AMMS)
- Meng Wei
- Beijing Institute of Biotechnology, Academy of Military Medical Sciences (AMMS)
- Yunhai Mo
- Beijing Institute of Biotechnology, Academy of Military Medical Sciences (AMMS)
- Xuetao Mu
- Department of Clinical Laboratory, the Third Medical Center, Chinese PLA General Hospital
- Xiaowei Deng
- Department of Clinical Laboratory, the Third Medical Center, Chinese PLA General Hospital
- Dandan Zhang
- Department of Clinical Laboratory, the Third Medical Center, Chinese PLA General Hospital
- Siqing Dong
- Department of Clinical Laboratory, the Third Medical Center, Chinese PLA General Hospital
- Hanqing Huang
- Beijing Institute of Biotechnology, Academy of Military Medical Sciences (AMMS)
- Yi Fang
- Department of Endocrinology, the Fifth Medical Centre, Chinese PLA General Hospital
- Qi Gao
- Beijing Sungen Biomedical Technology Co., Ltd.
- Xiaoli Yang
- Department of Clinical Laboratory, the Third Medical Center, Chinese PLA General Hospital
- Feixiang Wu
- Department of Hepatobiliary Surgery, Affiliated Tumor Hospital of Guangxi Medical University
- Hui Zhong
- Beijing Institute of Biotechnology, Academy of Military Medical Sciences (AMMS)
- Congwen Wei
- Beijing Institute of Biotechnology, Academy of Military Medical Sciences (AMMS)
- DOI
- https://doi.org/10.1038/s41467-021-27309-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Dysregulation of lipid metabolism and transport contribute to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Here the authors identify GP73 as a TBC-domain Rab GTPase-activating protein that regulates very low-density lipoprotein export and promotes NAFLD development in mice.
