Simple 3D printed stainless steel microreactors for online mass spectrometric analysis

Gianmario Scotti; Sofia M.E. Nilsson; Ville-Pekka Matilainen; Markus Haapala; Gustav Boije af Gennäs; Jari Yli-Kauhaluoma; Antti Salminen; Tapio Kotiaho

Heliyon (Jul 2019)

Simple 3D printed stainless steel microreactors for online mass spectrometric analysis

Gianmario Scotti,
Sofia M.E. Nilsson,
Ville-Pekka Matilainen,
Markus Haapala,
Gustav Boije af Gennäs,
Jari Yli-Kauhaluoma,
Antti Salminen,
Tapio Kotiaho

Affiliations

Gianmario Scotti: Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, P.O. Box 56 (Viikinkaari 5 E), FI-00014, University of Helsinki, Finland; Corresponding author.
Sofia M.E. Nilsson: Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, P.O. Box 56 (Viikinkaari 5 E), FI-00014, University of Helsinki, Finland
Ville-Pekka Matilainen: Laser Processing Research Group, Lappeenranta University of Technology, Tuotantokatu 2, FI-53850, Lappeenranta, Finland
Markus Haapala: Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, P.O. Box 56 (Viikinkaari 5 E), FI-00014, University of Helsinki, Finland
Gustav Boije af Gennäs: Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, P.O. Box 56 (Viikinkaari 5 E), FI-00014, University of Helsinki, Finland
Jari Yli-Kauhaluoma: Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, P.O. Box 56 (Viikinkaari 5 E), FI-00014, University of Helsinki, Finland
Antti Salminen: Laser Processing Research Group, Lappeenranta University of Technology, Tuotantokatu 2, FI-53850, Lappeenranta, Finland
Tapio Kotiaho: Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, P.O. Box 56 (Viikinkaari 5 E), FI-00014, University of Helsinki, Finland; Department of Chemistry, Faculty of Science, P.O. Box 55 (A.I. Virtasen aukio 1), FI-00014, University of Helsinki, Finland; Corresponding author.

Journal volume & issue: Vol. 5, no. 7
p. e02002

Abstract

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A simple flow chemistry microreactor with an electrospray ionization tip for real time mass spectrometric reaction monitoring is introduced. The microreactor was fabricated by a laser-based additive manufacturing technique from acid-resistant stainless steel 316L. The functionality of the microreactor was investigated by using an inverse electron demand Diels-Alder and subsequent retro Diels-Alder reaction for testing. Challenges and problems encountered are discussed and improvements proposed. Adsorption of reagents to the rough stainless steel channel walls, short length of the reaction channel, and making a proper ESI tip present challenges, but the microreactor is potentially useful as a disposable device.

Published in Heliyon

ISSN: 2405-8440 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Science: Science (General); Social Sciences: Social sciences (General)
Website: https://www.cell.com/heliyon/home

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