Communications Biology (Nov 2022)
Reprogramming of pancreatic adenocarcinoma immunosurveillance by a microbial probiotic siderophore
- Mehdi Chaib,
- Bilal B. Hafeez,
- Hassan Mandil,
- Deidre Daria,
- Ajeeth K. Pingili,
- Sonam Kumari,
- Mohammed Sikander,
- Vivek K. Kashyap,
- Guo-Yun Chen,
- Emmanuel Anning,
- Manish K. Tripathi,
- Sheema Khan,
- Stephen Behrman,
- Murali M. Yallapu,
- Meena Jaggi,
- Liza Makowski,
- Subhash C. Chauhan
Affiliations
- Mehdi Chaib
- Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center (UTHSC)
- Bilal B. Hafeez
- Department of Immunology and Microbiology and South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley
- Hassan Mandil
- Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center (UTHSC)
- Deidre Daria
- Department of Microbiology, Immunology and Biochemistry
- Ajeeth K. Pingili
- Division of Hematology Oncology, Department of Medicine
- Sonam Kumari
- Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center (UTHSC)
- Mohammed Sikander
- Department of Immunology and Microbiology and South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley
- Vivek K. Kashyap
- Department of Immunology and Microbiology and South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley
- Guo-Yun Chen
- Children’s Foundation Research Institute at Le Bonheur Children’s Hospital, Department of Pediatrics
- Emmanuel Anning
- Department of Immunology and Microbiology and South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley
- Manish K. Tripathi
- Department of Immunology and Microbiology and South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley
- Sheema Khan
- Department of Immunology and Microbiology and South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley
- Stephen Behrman
- Department of Surgery
- Murali M. Yallapu
- Department of Immunology and Microbiology and South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley
- Meena Jaggi
- Department of Immunology and Microbiology and South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley
- Liza Makowski
- Department of Medicine, Division of Hematology and Oncology and the UTHSC Center for Cancer Research
- Subhash C. Chauhan
- Department of Immunology and Microbiology and South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley
- DOI
- https://doi.org/10.1038/s42003-022-04102-4
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 15
Abstract
The probiotic-derived siderophore, ferrichrome, enhances anti-tumor immunity and improves the efficacy of checkpoint immunotherapy in a model of pancreatic cancer by repolarizing tumor-associated macrophages to a immunostimulatory M1 phenotype.
