Kidney Medicine (Mar 2023)
CKD, Brain Atrophy, and White Matter Lesion Volume: The Japan Prospective Studies Collaboration for Aging and DementiaPlain-Language summary
- Kenji Maki,
- Tomoyuki Ohara,
- Jun Hata,
- Mao Shibata,
- Naoki Hirabayashi,
- Takanori Honda,
- Satoko Sakata,
- Yoshihiko Furuta,
- Masato Akiyama,
- Keisuke Yamasaki,
- Yasuko Tatewaki,
- Yasuyuki Taki,
- Takanari Kitazono,
- Tatsuya Mikami,
- Tetsuya Maeda,
- Kenjiro Ono,
- Masaru Mimura,
- Kenji Nakashima,
- Jun-ichi Iga,
- Minoru Takebayashi,
- Toshiharu Ninomiya,
- Toshiharu Ninomiya,
- Jun Hata,
- Mao Shibata,
- Takanori Honda,
- Tomoyuki Ohara,
- Masato Akiyama,
- Shigeyuki Nakaji,
- Koichi Murashita,
- Tatsuya Mikami,
- Songee Jung,
- Mina Misawa,
- Tetsuya Maeda,
- Naoki Ishizuka,
- Hiroshi Akasaka,
- Yasuo Terayama,
- Hisashi Yonezawa,
- Junko Takahashi,
- Kenjiro Ono,
- Moeko Noguchi-Shinohara,
- Junji Komatsu,
- Shutaro Shibata,
- Sohshi Yuki-Nozaki,
- Masaru Mimura,
- Shogyoku Bun,
- Hidehito Niimura,
- Ryo Shikimoto,
- Hisashi Kida,
- Kenji Nakashima,
- Yasuyo Fukada,
- Hisanori Kowa,
- Toshiya Nakano,
- Kenji Wada,
- Masafumi Kishi,
- Tomoki Ozaki,
- Ayumi Tachibana,
- Yuta Yoshino,
- Jun-ichi Iga Shu-ichi Ueno,
- Minoru Takebayashi,
- Tomohisa Ishikawa,
- Seiji Yuki,
- Asuka Koyama,
- Naoto Kajitani,
- Mamoru Hashimoto,
- Manabu Ikeda,
- Yoshihiro Kokubo,
- Kazuhiro Uchida,
- Midori Esaki,
- Yasuyuki Taki,
- Yasuko Tatewaki,
- Benjamin Thyreau,
- Koji Yonemoto,
- Hisako Yoshida,
- Kaori Muto,
- Yusuke Inoue,
- Izen Ri,
- Yukihide Momozawa,
- Chikashi Terao,
- Michiaki Kubo,
- Yutaka Kiyohara
Affiliations
- Kenji Maki
- Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
- Tomoyuki Ohara
- Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Address for Correspondence: Tomoyuki Ohara, MD, PhD, Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
- Jun Hata
- Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
- Mao Shibata
- Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
- Naoki Hirabayashi
- Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
- Takanori Honda
- Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
- Satoko Sakata
- Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
- Yoshihiko Furuta
- Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
- Masato Akiyama
- Department of Ocular Pathology and Imaging Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
- Keisuke Yamasaki
- Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
- Yasuko Tatewaki
- Department of Aging Research and Geriatric Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
- Yasuyuki Taki
- Department of Aging Research and Geriatric Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
- Takanari Kitazono
- Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
- Tatsuya Mikami
- Department of Preemptive Medicine, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan
- Tetsuya Maeda
- Division of Neurology and Gerontology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Iwate, Japan
- Kenjiro Ono
- Department of Neurology, Kanazawa University Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan
- Masaru Mimura
- Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan
- Kenji Nakashima
- National Hospital Organization, Matsue Medical Center, Shimane, Japan
- Jun-ichi Iga
- Department of Neuropsychiatry, Ehime University Graduate School of Medicine, Ehime University, Ehime, Japan
- Minoru Takebayashi
- Faculty of Life Sciences, Department of Neuropsychiatry, Kumamoto University, Kumamoto, Japan
- Toshiharu Ninomiya
- Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
- Toshiharu Ninomiya
- Jun Hata
- Mao Shibata
- Takanori Honda
- Tomoyuki Ohara
- Masato Akiyama
- Shigeyuki Nakaji
- Koichi Murashita
- Tatsuya Mikami
- Songee Jung
- Mina Misawa
- Tetsuya Maeda
- Naoki Ishizuka
- Hiroshi Akasaka
- Yasuo Terayama
- Hisashi Yonezawa
- Junko Takahashi
- Kenjiro Ono
- Moeko Noguchi-Shinohara
- Junji Komatsu
- Shutaro Shibata
- Sohshi Yuki-Nozaki
- Masaru Mimura
- Shogyoku Bun
- Hidehito Niimura
- Ryo Shikimoto
- Hisashi Kida
- Kenji Nakashima
- Yasuyo Fukada
- Hisanori Kowa
- Toshiya Nakano
- Kenji Wada
- Masafumi Kishi
- Tomoki Ozaki
- Ayumi Tachibana
- Yuta Yoshino
- Jun-ichi Iga Shu-ichi Ueno
- Minoru Takebayashi
- Tomohisa Ishikawa
- Seiji Yuki
- Asuka Koyama
- Naoto Kajitani
- Mamoru Hashimoto
- Manabu Ikeda
- Yoshihiro Kokubo
- Kazuhiro Uchida
- Midori Esaki
- Yasuyuki Taki
- Yasuko Tatewaki
- Benjamin Thyreau
- Koji Yonemoto
- Hisako Yoshida
- Kaori Muto
- Yusuke Inoue
- Izen Ri
- Yukihide Momozawa
- Chikashi Terao
- Michiaki Kubo
- Yutaka Kiyohara
- Journal volume & issue
-
Vol. 5,
no. 3
p. 100593
Abstract
Rationale & Objective: Chronic kidney disease, defined by albuminuria and/or reduced estimated glomerular filtration rate (eGFR), has been reported to be associated with brain atrophy and/or higher white matter lesion volume (WMLV), but there are few large-scale population-based studies assessing this issue. This study aimed to examine the associations between the urinary albumin-creatinine ratio (UACR) and eGFR levels and brain atrophy and WMLV in a large-scale community-dwelling older population of Japanese. Study Design: Population-based cross-sectional study. Setting & Participants: A total of 8,630 dementia-free community-dwelling Japanese aged greater than or equal to 65 years underwent brain magnetic resonance imaging scanning and screening examination of health status in 2016-2018. Exposures: UACR and eGFR levels. Outcomes: The total brain volume (TBV)-to-intracranial volume (ICV) ratio (TBV/ICV), the regional brain volume-to-TBV ratio, and the WMLV-to-ICV ratio (WMLV/ICV). Analytical Approach: The associations of UACR and eGFR levels with the TBV/ICV, the regional brain volume-to-TBV ratio, and the WMLV/ICV were assessed by using an analysis of covariance. Results: Higher UACR levels were significantly associated with lower TBV/ICV and higher geometric mean values of the WMLV/ICV (P for trend = 0.009 and <0.001, respectively). Lower eGFR levels were significantly associated with lower TBV/ICV, but not clearly associated with WMLV/ICV. In addition, higher UACR levels, but not lower eGFR, were significantly associated with lower temporal cortex volume-to-TBV ratio and lower hippocampal volume-to-TBV ratio. Limitations: Cross-sectional study, misclassification of UACR or eGFR levels, generalizability to other ethnicities and younger populations, and residual confounding factors. Conclusions: The present study demonstrated that higher UACR was associated with brain atrophy, especially in the temporal cortex and hippocampus, and with increased WMLV. These findings suggest that chronic kidney disease is involved in the progression of morphologic brain changes associated with cognitive impairment.
