Computational identification of HCV neutralizing antibodies with a common HCDR3 disulfide bond motif in the antibody repertoires of infected individuals

Nina G. Bozhanova; Andrew I. Flyak; Benjamin P. Brown; Stormy E. Ruiz; Jordan Salas; Semi Rho; Robin G. Bombardi; Luke Myers; Cinque Soto; Justin R. Bailey; James E. Crowe; Pamela J. Bjorkman; Jens Meiler

doi:10.1038/s41467-022-30865-9

Nature Communications (Jun 2022)

Computational identification of HCV neutralizing antibodies with a common HCDR3 disulfide bond motif in the antibody repertoires of infected individuals

Nina G. Bozhanova,
Andrew I. Flyak,
Benjamin P. Brown,
Stormy E. Ruiz,
Jordan Salas,
Semi Rho,
Robin G. Bombardi,
Luke Myers,
Cinque Soto,
Justin R. Bailey,
James E. Crowe,
Pamela J. Bjorkman,
Jens Meiler

Affiliations

Nina G. Bozhanova: Department of Chemistry, Vanderbilt University
Andrew I. Flyak: Division of Biology and Biological Engineering, California Institute of Technology
Benjamin P. Brown: Department of Chemistry, Vanderbilt University
Stormy E. Ruiz: Division of Biology and Biological Engineering, California Institute of Technology
Jordan Salas: Department of Medicine, Johns Hopkins University School of Medicine
Semi Rho: Division of Biology and Biological Engineering, California Institute of Technology
Robin G. Bombardi: Vanderbilt Vaccine Center, Vanderbilt University Medical Center
Luke Myers: Vanderbilt Vaccine Center, Vanderbilt University Medical Center
Cinque Soto: Vanderbilt Vaccine Center, Vanderbilt University Medical Center
Justin R. Bailey: Department of Medicine, Johns Hopkins University School of Medicine
James E. Crowe: Vanderbilt Vaccine Center, Vanderbilt University Medical Center
Pamela J. Bjorkman: Division of Biology and Biological Engineering, California Institute of Technology
Jens Meiler: Department of Chemistry, Vanderbilt University

DOI: https://doi.org/10.1038/s41467-022-30865-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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Identifying determinants of broadly neutralizing antibodies against hepatitis C virus (HCV) may guide HCV vaccine design. Here, the authors discover new anti-HCV antibodies using computational screening and analyze the amino acid composition and sequence-structure relationships in this antibody family.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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