Nature Communications (Jan 2023)
Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4)
- Yan Chen,
- Qingtong Zhou,
- Jiang Wang,
- Youwei Xu,
- Yun Wang,
- Jiahui Yan,
- Yibing Wang,
- Qi Zhu,
- Fenghui Zhao,
- Chenghao Li,
- Chuan-Wei Chen,
- Xiaoqing Cai,
- Ross A .D. Bathgate,
- Chun Shen,
- H. Eric Xu,
- Dehua Yang,
- Hong Liu,
- Ming-Wei Wang
Affiliations
- Yan Chen
- Department of Pharmacology, School of Basic Medical Sciences, Fudan University
- Qingtong Zhou
- Department of Pharmacology, School of Basic Medical Sciences, Fudan University
- Jiang Wang
- State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Youwei Xu
- The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Yun Wang
- Genova Biotech (Changzhou) Co., Ltd
- Jiahui Yan
- The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Yibing Wang
- State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Qi Zhu
- Genova Biotech (Changzhou) Co., Ltd
- Fenghui Zhao
- The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Chenghao Li
- State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Chuan-Wei Chen
- Research Center for Deepsea Bioresources
- Xiaoqing Cai
- The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Ross A .D. Bathgate
- The Florey Institute of Neuroscience and Mental Health, University of Melbourne
- Chun Shen
- Genova Biotech (Changzhou) Co., Ltd
- H. Eric Xu
- The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Dehua Yang
- The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Hong Liu
- State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Ming-Wei Wang
- Department of Pharmacology, School of Basic Medical Sciences, Fudan University
- DOI
- https://doi.org/10.1038/s41467-023-36182-z
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 15
Abstract
Relaxin family peptide receptor 4 (RXFP4) regulates pleiotropic biological processes. Here, authors report cryo-EM structures revealing the ligand-binding modes and key determinants of peptidomimetic agonism and subtype selectivity
