Guillain-Barré syndrome and fulminant encephalomyelitis following Ad26.COV2.S vaccination: double jeopardy

Maria Ioanna Stefanou; Eleni Karachaliou; Maria Chondrogianni; Christos Moschovos; Eleni Bakola; Aikaterini Foska; Konstantinos Melanis; Elisabeth Andreadou; Konstantinos Voumvourakis; Matilda Papathanasiou; Eleni Boutati; Georgios Tsivgoulis

doi:10.1186/s42466-022-00172-1

Neurological Research and Practice (Feb 2022)

Guillain-Barré syndrome and fulminant encephalomyelitis following Ad26.COV2.S vaccination: double jeopardy

Maria Ioanna Stefanou,
Eleni Karachaliou,
Maria Chondrogianni,
Christos Moschovos,
Eleni Bakola,
Aikaterini Foska,
Konstantinos Melanis,
Elisabeth Andreadou,
Konstantinos Voumvourakis,
Matilda Papathanasiou,
Eleni Boutati,
Georgios Tsivgoulis

Affiliations

Maria Ioanna Stefanou: Second Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, “Attikon” University Hospital
Eleni Karachaliou: Second Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, “Attikon” University Hospital
Maria Chondrogianni: Second Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, “Attikon” University Hospital
Christos Moschovos: Second Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, “Attikon” University Hospital
Eleni Bakola: Second Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, “Attikon” University Hospital
Aikaterini Foska: Second Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, “Attikon” University Hospital
Konstantinos Melanis: Second Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, “Attikon” University Hospital
Elisabeth Andreadou: First Department of Neurology, Aeginition Hospital, National and Kapodistrian University of Athens
Konstantinos Voumvourakis: Second Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, “Attikon” University Hospital
Matilda Papathanasiou: Second Department of Radiology, National and Kapodistrian University of Athens, School of Medicine, “Attikon” University Hospital
Eleni Boutati: Second Department of Internal Medicine, National and Kapodistrian University of Athens, School of Medicine, “Attikon” University Hospital
Georgios Tsivgoulis: Second Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, “Attikon” University Hospital

DOI: https://doi.org/10.1186/s42466-022-00172-1
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 4

Abstract

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Abstract This correspondence comments on a published article presenting a case of rhombencephalitis following SARS-CoV-2-vaccination with the mRNA vaccine BNT162b2 (Pfizer/BioNTech). We also present the case of a 47-year-old man who developed Guillain-Barré-syndrome and a fulminant encephalomyelitis 28 days after immunization with Ad26.COV2.S (Janssen/Johnson & Johnson). Based on the presented cases, we underscore the importance of clinical awareness for early recognition of overlapping neuroimmunological syndromes following vaccination against SARS-CoV-2. Additionally, we propose that that role of autoantibodies against angiotensin-converting enzyme 2 (ACE2) and the cell-surface receptor neuropilin-1, which mediate neurological manifestations of SARS-CoV-2, merit further investigation in patients presenting with neurological disorders following vaccination against SARS-CoV-2.

Published in Neurological Research and Practice

ISSN: 2524-3489 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://neurolrespract.biomedcentral.com/

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Abstract

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