International Journal of General Medicine (Mar 2023)
Inflammatory Markers in Women with Infertility: A Cross-Sectional Study
Abstract
Yanan Duan,1 Ye Zhou,2 Yiqing Peng,2 Xiuling Shi,2 Cunxu Peng2 1Jining Medical University, Jining, Shandong Province, 272002, People’s Republic of China; 2Department of Gynecology, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, 272029, People’s Republic of ChinaCorrespondence: Cunxu Peng, Affiliated Hospital of Jining Medical University, 89 Guhuai Road, Rencheng District, Jining City, Shandong Province, People’s Republic of China, Tel +86 13385405627, Fax +86 0530-6533898, Email [email protected]: Infertility is highly correlated with inflammation. We sought to evaluate the independent relationships between each inflammatory marker in women with infertility.Patients and Methods: This cross-sectional study included 1028 infertile patients who were hospitalized at Jining Medical University between January 2016 and December 2022. NLR and PLR were the independent and dependent variables measured at baseline, respectively. Age, body mass index (BMI), and menstrual status were covariates. Based on BMI, the study population was split into two groups: Low-BMI and High-BMI.Results: A stratified analysis revealed that the overweight group had significantly higher levels of WBC, platelet count, lymphocyte count, neutrophil count and NLR. Comparing the overweight group to the normal weight group, the levels were noticeably higher in the overweight group. Significantly positive correlations between NLR and PLR were found in both univariate and multiple regression analyses.Conclusion: There was a significant positive correlation between NLR and PLR in infertility patients. These results will help in the search for biomarkers of infertility and in the development of infertility prediction models.Keywords: infertility, inflammation marker, PLR, NLR, lymphocyte count
