EXPERIMENTAL STUDY OF THE USE OF OSTEO-CELLULAR GRAFTS IN WRIST ARTHRODESIS

Abstract

Introduction. Wrist arthrodesis is a surgery performed in advanced osteoarthritis of the wrist joint of various etiology, posttraumatic consequences or diseases of carpal bones. It is a rescue surgery and is performed with the cost of losing of range of movement, but remove the pain syndrome and increase the strength of the hand. Aim of study. Evaluation of osteo-cellular grafts (OCG) using in wrist arthrodesis in experimental study on laboratory animals. Material and Methods. The study was based on experimental research on 21 New Zealand rabbits, splited in 3 study groups. As methods of implementation of the study included: preparation of allogeneic demineralized bone grafts, bone marrow sampling and isolation of autologous stem cells, obtaining OCG, and performing 3 different techniques of wrist arthrodesis. Results. Imagistic results showed us, that the group were performed arthrodesis using combined graft with stem cells, the ankylosis were achieved faster. Histological examinations indicated more active involvement in the process of osteogenesis in the use of combined stem cell transplantation. Conclusion. Our study showed that compared to the control group, the arthrodesis of the wrist using the allograft have good impact in the process of osteogenesis, but the best results were performed by using allograft combined with stem cells.

Keywords

• wrist arthrodesis
• autologous stem cells
• osteo-cellular graft