Reproductive Biology and Endocrinology (Nov 2012)

A new ovarian response prediction index (ORPI): implications for individualised controlled ovarian stimulation

  • Oliveira Joao Batista A,
  • Baruffi Ricardo LR,
  • Petersen Claudia G,
  • Mauri Ana L,
  • Nascimento Adriana M,
  • Vagnini Laura,
  • Ricci Juliana,
  • Cavagna Mario,
  • Franco Jose G

DOI
https://doi.org/10.1186/1477-7827-10-94
Journal volume & issue
Vol. 10, no. 1
p. 94

Abstract

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Abstract Background The objective was to present a new ovarian response prediction index (ORPI), which was based on anti-Müllerian hormone (AMH) levels, antral follicle count (AFC) and age, and to verify whether it could be a reliable predictor of the ovarian stimulation response. Methods A total of 101 patients enrolled in the ICSI programme were included. The ORPI values were calculated by multiplying the AMH level (ng/ml) by the number of antral follicles (2–9 mm), and the result was divided by the age (years) of the patient (ORPI=(AMH x AFC)/Patient age). Results The regression analysis demonstrated significant (PP=0.006) and collecting greater than or equal to 4 oocytes (OR: 49.25; PPP Conclusions The ORPI exhibited an excellent ability to predict a low ovarian response and a good ability to predict a collection of greater than or equal to 4 MII oocytes, an excessive ovarian response and the occurrence of pregnancy in infertile women. The ORPI might be used to improve the cost-benefit ratio of ovarian stimulation regimens by guiding the selection of medications and by modulating the doses and regimens according to the actual needs of the patients.

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