Structural Dynamics (Jul 2015)
The linac coherent light source single particle imaging road map
- A. Aquila,
- A. Barty,
- C. Bostedt,
- S. Boutet,
- G. Carini,
- D. dePonte,
- P. Drell,
- S. Doniach,
- K. H. Downing,
- T. Earnest,
- H. Elmlund,
- V. Elser,
- M. Gühr,
- J. Hajdu,
- J. Hastings,
- S. P. Hau-Riege,
- Z. Huang,
- E. E. Lattman,
- F. R. N. C. Maia,
- S. Marchesini,
- A. Ourmazd,
- C. Pellegrini,
- R. Santra,
- I. Schlichting,
- C. Schroer,
- J. C. H. Spence,
- I. A. Vartanyants,
- S. Wakatsuki,
- W. I. Weis,
- G. J. Williams
Affiliations
- A. Aquila
- SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025, USA
- A. Barty
- Center for Free-Electron Laser Science, DESY, Notkestr. 85, 22607 Hamburg, Germany
- C. Bostedt
- SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025, USA
- S. Boutet
- SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025, USA
- G. Carini
- SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025, USA
- D. dePonte
- SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025, USA
- P. Drell
- SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025, USA
- S. Doniach
- SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025, USA
- K. H. Downing
- Lawrence Berkeley National Laboratory, 1 Cyclotron Rd., Berkeley, California 94720, USA
- T. Earnest
- Shanghai Institute of Applied Physics, Chinese Academy of Sciences, 239 Zhangheng Road, Shanghai 201204, China
- H. Elmlund
- Department of Biochemistry Molecular Biology, Monash University, Clayton 3800, Australia
- V. Elser
- SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025, USA
- M. Gühr
- PULSE Institute, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025, USA
- J. Hajdu
- Laboratory of Molecular Biophysics, Department of Cell and Molecular Biology, Uppsala University, Husargatan 3, 75124 Uppsala, Sweden
- J. Hastings
- SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025, USA
- S. P. Hau-Riege
- Lawrence Livermore National Laboratory, Livermore, California 94550, USA
- Z. Huang
- SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025, USA
- E. E. Lattman
- BioXFEL Center and Department of Structural Biology, University at Buffalo, SUNY, 700 Ellicott Street, Buffalo, New York 14203, USA
- F. R. N. C. Maia
- Laboratory of Molecular Biophysics, Department of Cell and Molecular Biology, Uppsala University, Husargatan 3, 75124 Uppsala, Sweden
- S. Marchesini
- Lawrence Berkeley National Laboratory, 1 Cyclotron Rd., Berkeley, California 94720, USA
- A. Ourmazd
- Department of Physics, University of Wisconsin Milwaukee, 1900 E. Kenwood Blvd, Milwaukee, Wisconsin 53211, USA
- C. Pellegrini
- SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025, USA
- R. Santra
- Center for Free-Electron Laser Science, DESY, Notkestr. 85, 22607 Hamburg, Germany
- I. Schlichting
- Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
- C. Schroer
- Deutsches Elektronen-Synchrotron DESY, Notkestraße 85, 22607 Hamburg, Germany
- J. C. H. Spence
- Department of Physics, Arizona State University, Rural Rd, Tempe, Arizona 85287, USA
- I. A. Vartanyants
- Deutsches Elektronen-Synchrotron DESY, Notkestraße 85, 22607 Hamburg, Germany
- S. Wakatsuki
- SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025, USA
- W. I. Weis
- School of Medicine, Stanford University, 299 Campus Drive, Stanford, California 94305, USA
- G. J. Williams
- SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025, USA
- DOI
- https://doi.org/10.1063/1.4918726
- Journal volume & issue
-
Vol. 2,
no. 4
pp. 041701 – 041701-13
Abstract
Intense femtosecond x-ray pulses from free-electron laser sources allow the imaging of individual particles in a single shot. Early experiments at the Linac Coherent Light Source (LCLS) have led to rapid progress in the field and, so far, coherent diffractive images have been recorded from biological specimens, aerosols, and quantum systems with a few-tens-of-nanometers resolution. In March 2014, LCLS held a workshop to discuss the scientific and technical challenges for reaching the ultimate goal of atomic resolution with single-shot coherent diffractive imaging. This paper summarizes the workshop findings and presents the roadmap toward reaching atomic resolution, 3D imaging at free-electron laser sources.
