Adrenocortical carcinoma: A tumor with poor answer to classic chemotherapy

Abstract

Introduction: Adrenocortical carcinoma (ACC) represents a rare endocrine malignancy being the second most aggressive endocrine cancer after anaplastic thyroid cancer. [1]. While most of them arise sporadically, up to 15% of adult ACC patients are related to germline mutations associated with familial cancer syndromes.[1,2]. Current treatment strategies include surgery as well as systemic therapy with mitotane and chemotherapy.

Keywords

• adrenocortical carcinoma
• weiss score
• familial cancer syndromes
• mitotane