HFIP-Promoted Bischler Indole Synthesis under Microwave Irradiation

Abstract

1,1,1,3,3,3-Hexafluoropropan-2-ol (HFIP) was found to be effective for the Bischler indole synthesis under microwave irradiation in the absence of a metal catalyst. Under the catalysis of HFIP, a wide range of α-amino arylacetones were successfully transformed into indole derivatives with moderate to good yields.

Keywords

• indole
• cyclization
• microwave synthesis