Nature Communications (Nov 2022)

YAP promotes cell-autonomous immune responses to tackle intracellular Staphylococcus aureus in vitro

  • Robin Caire,
  • Estelle Audoux,
  • Mireille Thomas,
  • Elisa Dalix,
  • Aurélien Peyron,
  • Killian Rodriguez,
  • Nicola Pordone,
  • Johann Guillemot,
  • Yann Dickerscheit,
  • Hubert Marotte,
  • François Vandenesch,
  • Frédéric Laurent,
  • Jérôme Josse,
  • Paul O. Verhoeven

DOI
https://doi.org/10.1038/s41467-022-34432-0
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 19

Abstract

Read online

Growing evidence indicates that YAP/TAZ transcriptional regulators promote autophagy. Here, the authors characterize the role of YAP against Staphyloccocus aureus infection of synovial organoids and describe the role staphylococcal toxins have in antagonizing YAP-mediated functions.