Ferroptosis-associated circular RNAs: Opportunities and challenges in the diagnosis and treatment of cancer

Ruotong Yang; Ruotong Yang; Liwei Ma; Liwei Ma; Junhu Wan; Junhu Wan; Zhuofang Li; Zhuofang Li; Zhengwu Yang; Zhengwu Yang; Zhuochen Zhao; Zhuochen Zhao; Liang Ming; Liang Ming

doi:10.3389/fcell.2023.1160381

Frontiers in Cell and Developmental Biology (Apr 2023)

Ferroptosis-associated circular RNAs: Opportunities and challenges in the diagnosis and treatment of cancer

Ruotong Yang,
Ruotong Yang,
Liwei Ma,
Liwei Ma,
Junhu Wan,
Junhu Wan,
Zhuofang Li,
Zhuofang Li,
Zhengwu Yang,
Zhengwu Yang,
Zhuochen Zhao,
Zhuochen Zhao,
Liang Ming,
Liang Ming

Affiliations

Ruotong Yang: Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Ruotong Yang: Key Clinical Laboratory of Henan Province, Zhengzhou, China
Liwei Ma: Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Liwei Ma: Key Clinical Laboratory of Henan Province, Zhengzhou, China
Junhu Wan: Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Junhu Wan: Key Clinical Laboratory of Henan Province, Zhengzhou, China
Zhuofang Li: Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Zhuofang Li: Key Clinical Laboratory of Henan Province, Zhengzhou, China
Zhengwu Yang: Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Zhengwu Yang: Key Clinical Laboratory of Henan Province, Zhengzhou, China
Zhuochen Zhao: Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Zhuochen Zhao: Key Clinical Laboratory of Henan Province, Zhengzhou, China
Liang Ming: Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Liang Ming: Key Clinical Laboratory of Henan Province, Zhengzhou, China

DOI: https://doi.org/10.3389/fcell.2023.1160381
Journal volume & issue: Vol. 11

Abstract

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Ferroptosis is an emerging form of non-apoptotic regulated cell death which is different from cell death mechanisms such as autophagy, apoptosis and necrosis. It is characterized by iron-dependent lipid peroxide accumulation. Circular RNA (circRNA) is a newly studied evolutionarily conserved type of non-coding RNA with a covalent closed-loop structure. It exhibits universality, conservatism, stability and particularity. At present, the functions that have been studied and found include microRNA sponge, protein scaffold, transcription regulation, translation and production of peptides, etc. CircRNA can be used as a biomarker of tumors and is a hotspot in RNA biology research. Studies have shown that ferroptosis can participate in tumor regulation through the circRNA molecular pathway and then affect cancer progression, which may become a direction of cancer diagnosis and treatment in the future. This paper reviews the molecular biological mechanism of ferroptosis and the role of circular RNA in tumors and summarizes the circRNA related to ferroptosis in tumors, which may inspire research prospects for the precise prevention and treatment of cancer in the future.

Published in Frontiers in Cell and Developmental Biology

ISSN: 2296-634X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/cell-and-developmental-biology

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