Nature Communications (Jan 2021)
Regulatory protein HilD stimulates Salmonella Typhimurium invasiveness by promoting smooth swimming via the methyl-accepting chemotaxis protein McpC
- Kendal G. Cooper,
- Audrey Chong,
- Laszlo Kari,
- Brendan Jeffrey,
- Tregei Starr,
- Craig Martens,
- Molly McClurg,
- Victoria R. Posada,
- Richard C. Laughlin,
- Canaan Whitfield-Cargile,
- L. Garry Adams,
- Laura K. Bryan,
- Sara V. Little,
- Mary Krath,
- Sara D. Lawhon,
- Olivia Steele-Mortimer
Affiliations
- Kendal G. Cooper
- Laboratory of Bacteriology, Rocky Mountain Laboratory, National Institutes of Allergy and Infectious Diseases, National Institutes of Health
- Audrey Chong
- Laboratory of Bacteriology, Rocky Mountain Laboratory, National Institutes of Allergy and Infectious Diseases, National Institutes of Health
- Laszlo Kari
- Laboratory of Bacteriology, Rocky Mountain Laboratory, National Institutes of Allergy and Infectious Diseases, National Institutes of Health
- Brendan Jeffrey
- NIAID Bioinformatics and Computational Biosciences Branch, Rocky Mountain Laboratory, National Institutes of Allergy and Infectious Diseases, National Institutes of Health
- Tregei Starr
- Laboratory of Bacteriology, Rocky Mountain Laboratory, National Institutes of Allergy and Infectious Diseases, National Institutes of Health
- Craig Martens
- NIAID RML Research Technologies Section, Genomics Unit, Rocky Mountain Laboratory, National Institutes of Allergy and Infectious Diseases, National Institutes of Health
- Molly McClurg
- Department of Biological and Health Sciences, Texas A&M University-Kingsville
- Victoria R. Posada
- Department of Biological and Health Sciences, Texas A&M University-Kingsville
- Richard C. Laughlin
- Department of Biological and Health Sciences, Texas A&M University-Kingsville
- Canaan Whitfield-Cargile
- Department of Veterinary Large Animal Clinical Sciences, Texas A&M College of Veterinary Medicine and Biomedical Sciences
- L. Garry Adams
- Department of Veterinary Pathobiology, Texas A&M College of Veterinary Medicine and Biomedical Sciences
- Laura K. Bryan
- Department of Veterinary Pathobiology, Texas A&M College of Veterinary Medicine and Biomedical Sciences
- Sara V. Little
- Department of Veterinary Pathobiology, Texas A&M College of Veterinary Medicine and Biomedical Sciences
- Mary Krath
- Department of Veterinary Pathobiology, Texas A&M College of Veterinary Medicine and Biomedical Sciences
- Sara D. Lawhon
- Department of Veterinary Pathobiology, Texas A&M College of Veterinary Medicine and Biomedical Sciences
- Olivia Steele-Mortimer
- Laboratory of Bacteriology, Rocky Mountain Laboratory, National Institutes of Allergy and Infectious Diseases, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-020-20558-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Protein HilD of Salmonella Typhimurium coordinates motility and host cell invasion by upregulating flagellar genes and a secretion system. Here, Cooper et al. show that HilD also modulates swimming behaviour by upregulating a subunit of the chemotactic receptor array, and this is important for invasion of epithelial cells.
