Nature Communications (Jan 2022)
Single cell transcriptomic landscape of diabetic foot ulcers
- Georgios Theocharidis,
- Beena E. Thomas,
- Debasree Sarkar,
- Hope L. Mumme,
- William J. R. Pilcher,
- Bhakti Dwivedi,
- Teresa Sandoval-Schaefer,
- Ruxandra F. Sîrbulescu,
- Antonios Kafanas,
- Ikram Mezghani,
- Peng Wang,
- Antonio Lobao,
- Ioannis S. Vlachos,
- Biraja Dash,
- Henry C. Hsia,
- Valerie Horsley,
- Swati S. Bhasin,
- Aristidis Veves,
- Manoj Bhasin
Affiliations
- Georgios Theocharidis
- The Rongxiang Xu, MD, Center for Regenerative Therapeutics and Joslin-Beth Israel Deaconess Foot Center, Beth Israel Deaconess Medical Center and Harvard Medical School
- Beena E. Thomas
- Aflac Cancer and Blood Disorders Center, Children Healthcare of Atlanta, Department of Pediatrics and Biomedical Informatics, Emory University
- Debasree Sarkar
- Aflac Cancer and Blood Disorders Center, Children Healthcare of Atlanta, Department of Pediatrics and Biomedical Informatics, Emory University
- Hope L. Mumme
- Aflac Cancer and Blood Disorders Center, Children Healthcare of Atlanta, Department of Pediatrics and Biomedical Informatics, Emory University
- William J. R. Pilcher
- Aflac Cancer and Blood Disorders Center, Children Healthcare of Atlanta, Department of Pediatrics and Biomedical Informatics, Emory University
- Bhakti Dwivedi
- Winship Cancer Institute, Emory University
- Teresa Sandoval-Schaefer
- Molecular, Cellular and Developmental Biology, Yale University
- Ruxandra F. Sîrbulescu
- Vaccine and Immunotherapy Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School
- Antonios Kafanas
- Lincoln County Hospital, Northern Lincolnshire and Goole NHS Foundation Trust
- Ikram Mezghani
- The Rongxiang Xu, MD, Center for Regenerative Therapeutics and Joslin-Beth Israel Deaconess Foot Center, Beth Israel Deaconess Medical Center and Harvard Medical School
- Peng Wang
- The Rongxiang Xu, MD, Center for Regenerative Therapeutics and Joslin-Beth Israel Deaconess Foot Center, Beth Israel Deaconess Medical Center and Harvard Medical School
- Antonio Lobao
- The Rongxiang Xu, MD, Center for Regenerative Therapeutics and Joslin-Beth Israel Deaconess Foot Center, Beth Israel Deaconess Medical Center and Harvard Medical School
- Ioannis S. Vlachos
- Department of Pathology, Beth Israel Deaconess Medical Center, and Harvard Medical School
- Biraja Dash
- Yale Plastic and Reconstructive Surgery-Wound Center, Yale School of Medicine
- Henry C. Hsia
- Yale Plastic and Reconstructive Surgery-Wound Center, Yale School of Medicine
- Valerie Horsley
- Molecular, Cellular and Developmental Biology, Yale University
- Swati S. Bhasin
- Aflac Cancer and Blood Disorders Center, Children Healthcare of Atlanta, Department of Pediatrics and Biomedical Informatics, Emory University
- Aristidis Veves
- The Rongxiang Xu, MD, Center for Regenerative Therapeutics and Joslin-Beth Israel Deaconess Foot Center, Beth Israel Deaconess Medical Center and Harvard Medical School
- Manoj Bhasin
- Aflac Cancer and Blood Disorders Center, Children Healthcare of Atlanta, Department of Pediatrics and Biomedical Informatics, Emory University
- DOI
- https://doi.org/10.1038/s41467-021-27801-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Diabetic foot ulcers (DFUs) remain a complication of diabetes that are difficult to heal and lead to disability. Here the authors use single-cell RNA-sequencing and spatial transcriptomics to characterize the DFU cellular landscape and identify a population of fibroblasts that is associated with successful wound closure.
