Local Phenomena Shape Backyard Soil Metabolite Composition

Tra  D. Nguyen; Mahbobeh Lesani; Ines Forrest; Yunpeng Lan; Danya  A. Dean; Quentin  M. R. Gibaut; Yanting Guo; Ekram Hossain; Marcela Olvera; Hannah Panlilio; Adwaita  R. Parab; Chaoyi Wu; Jean  A. Bernatchez; Robert  H. Cichewicz; Laura-Isobel McCall

doi:10.3390/metabo10030086

Metabolites (Feb 2020)

Local Phenomena Shape Backyard Soil Metabolite Composition

Tra D. Nguyen,
Mahbobeh Lesani,
Ines Forrest,
Yunpeng Lan,
Danya A. Dean,
Quentin M. R. Gibaut,
Yanting Guo,
Ekram Hossain,
Marcela Olvera,
Hannah Panlilio,
Adwaita R. Parab,
Chaoyi Wu,
Jean A. Bernatchez,
Robert H. Cichewicz,
Laura-Isobel McCall

Affiliations

Tra D. Nguyen: Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA
Mahbobeh Lesani: Department of Microbiology and Plant Biology, University of Oklahoma, Norman, OK 73019, USA
Ines Forrest: Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA
Yunpeng Lan: Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA
Danya A. Dean: Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA
Quentin M. R. Gibaut: Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA
Yanting Guo: Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA
Ekram Hossain: Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA
Marcela Olvera: Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA
Hannah Panlilio: Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA
Adwaita R. Parab: Department of Microbiology and Plant Biology, University of Oklahoma, Norman, OK 73019, USA
Chaoyi Wu: Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA
Jean A. Bernatchez: Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA
Robert H. Cichewicz: Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA
Laura-Isobel McCall: Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA

DOI: https://doi.org/10.3390/metabo10030086
Journal volume & issue: Vol. 10, no. 3
p. 86

Abstract

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Soil covers most of Earth’s continental surface and is fundamental to life-sustaining processes such as agriculture. Given its rich biodiversity, soil is also a major source for natural product drug discovery from soil microorganisms. However, the study of the soil small molecule profile has been challenging due to the complexity and heterogeneity of this matrix. In this study, we implemented high-resolution liquid chromatography−tandem mass spectrometry and large-scale data analysis tools such as molecular networking to characterize the relative contributions of city, state and regional processes on backyard soil metabolite composition, in 188 soil samples collected from 14 USA States, representing five USA climate regions. We observed that region, state and city of collection all influence the overall soil metabolite profile. However, many metabolites were only detected in unique sites, indicating that uniquely local phenomena also influence the backyard soil environment, with both human-derived and naturally-produced (plant-derived, microbially-derived) metabolites identified. Overall, these findings are helping to define the processes that shape the backyard soil metabolite composition, while also highlighting the need for expanded metabolomic studies of this complex environment.

Published in Metabolites

ISSN: 2218-1989 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.mdpi.com/journal/metabolites

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