Nature Communications (Jul 2019)
Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART
- Nadine Bachmann,
- Chantal von Siebenthal,
- Valentina Vongrad,
- Teja Turk,
- Kathrin Neumann,
- Niko Beerenwinkel,
- Jasmina Bogojeska,
- Jaques Fellay,
- Volker Roth,
- Yik Lim Kok,
- Christian W. Thorball,
- Alessandro Borghesi,
- Sonali Parbhoo,
- Mario Wieser,
- Jürg Böni,
- Matthieu Perreau,
- Thomas Klimkait,
- Sabine Yerly,
- Manuel Battegay,
- Andri Rauch,
- Matthias Hoffmann,
- Enos Bernasconi,
- Matthias Cavassini,
- Roger D. Kouyos,
- Huldrych F. Günthard,
- Karin J. Metzner,
- the Swiss HIV Cohort Study
Affiliations
- Nadine Bachmann
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich
- Chantal von Siebenthal
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich
- Valentina Vongrad
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich
- Teja Turk
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich
- Kathrin Neumann
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich
- Niko Beerenwinkel
- Department of Biosystems Science and Engineering, ETH Zurich
- Jasmina Bogojeska
- IBM Research—Zurich
- Jaques Fellay
- School of Life Sciences, EPFL
- Volker Roth
- Department of Mathematics and Computer Science, University of Basel
- Yik Lim Kok
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich
- Christian W. Thorball
- School of Life Sciences, EPFL
- Alessandro Borghesi
- School of Life Sciences, EPFL
- Sonali Parbhoo
- Department of Mathematics and Computer Science, University of Basel
- Mario Wieser
- Department of Mathematics and Computer Science, University of Basel
- Jürg Böni
- Institute of Medical Virology, University of Zurich
- Matthieu Perreau
- Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, University of Lausanne
- Thomas Klimkait
- Division Infection Diagnostics, Department Biomedicine—Petersplatz, University of Basel
- Sabine Yerly
- Division of Infectious Diseases and Laboratory of Virology, University Hospital Geneva, University of Geneva
- Manuel Battegay
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Basel
- Andri Rauch
- Department of Infectious Diseases, University Hospital Bern
- Matthias Hoffmann
- Division of Infectious Diseases, Cantonal Hospital of St. Gallen
- Enos Bernasconi
- Infectious Diseases Service, Regional Hospital
- Matthias Cavassini
- Division of Infectious Diseases, Centre Hospitalier Universitaire Vaudois, University of Lausanne
- Roger D. Kouyos
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich
- Huldrych F. Günthard
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich
- Karin J. Metzner
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich
- the Swiss HIV Cohort Study
- DOI
- https://doi.org/10.1038/s41467-019-10884-9
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
Here, Bachmann et al. provide data on long-term dynamics of the HIV-1 reservoir in 1,057 individuals on suppressive antiretroviral therapy and show that in 26.6% of individuals the reservoir increases. Viral blips and low-level viremia are significantly associated with a slower reservoir decay.
