Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation

Xue Yuan; Jay Cao; Xiaoning He; Rosa Serra; Jun Qu; Xu Cao; Shuying Yang

doi:10.1038/ncomms11024

Nature Communications (Mar 2016)

Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation

Xue Yuan,
Jay Cao,
Xiaoning He,
Rosa Serra,
Jun Qu,
Xu Cao,
Shuying Yang

Affiliations

Xue Yuan: Department of Oral Biology, School of Dental Medicine, University of Buffalo, The State University of New York, 3435 Main Street, Buffalo, New York 14214, USA
Jay Cao: USDA Grand Forks Human Nutrition Research Center
Xiaoning He: Department of Oral Biology, School of Dental Medicine, University of Buffalo, The State University of New York, 3435 Main Street, Buffalo, New York 14214, USA
Rosa Serra: Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham
Jun Qu: Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York
Xu Cao: Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine
Shuying Yang: Department of Oral Biology, School of Dental Medicine, University of Buffalo, The State University of New York, 3435 Main Street, Buffalo, New York 14214, USA

DOI: https://doi.org/10.1038/ncomms11024
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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Primary cilia are highly conserved microtubule-based organelles that play essential roles in several cellular processes including osteogenesis. Here the authors show that intraflagellar protein IFT80 regulates osteoblast differentiation by balancing signalling though the canonical and non-canonical Hedgehog pathways.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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