Prognosis Value of Serum Interleukin-17 and Procalcitonin in Elderly Patients withSevere Chronic Obstructive Pulmonary Disease Complicated with Pulmonary Infection

Abstract

Objective To observe the expression of serum interleukin(IL)-17 and procalcitonin(PCT) in elderly patients with severe chronic obstructive pulmonary disease(COPD) accompanied by pulmonary infection,and to explore their predictive value for the prognosis of patients. Methods A total of 120 elderly patients with severe COPD complicated with pulmonary infection admitted to Beijing Rehabilitation Hospital Affiliated with Capital Medical University from March 2021 to May 2022 were selected as the study subjects.All patients were followed up for 6 months. Serum IL-17 and PCT levels were measured,general data were collected,and the above data were statistically analyzed. Results At the end of follow-up,80 patients survived with a survival rate of 66.67% and 40 patients died with a mortality rate of 33.33%.There was no significant difference in gender,age,combined underlying diseases,smoking history and other data between the death group and the survival group(P>0.05);the serum IL-17 and PCT levels in the death group were higher than those in the survival group,and the duration of COPD and pulmonary infection was longer than those in the survival group,and the differences were statistically significant(P0.90. Conclusion Serum IL-17 and PCT levels are associated with prognosis in elderly patients with severe COPD with pulmonary infection and may be risk factors for increased risk of death.

Keywords

• chronic obstructive pulmonary disease
• elderly
• interleukin-17
• calcitoninogen
• prognosis