Nature Communications (Jul 2021)
An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer
- Rajdeep Das,
- Martin Sjöström,
- Raunak Shrestha,
- Christopher Yogodzinski,
- Emily A. Egusa,
- Lisa N. Chesner,
- William S. Chen,
- Jonathan Chou,
- Donna K. Dang,
- Jason T. Swinderman,
- Alex Ge,
- Junjie T. Hua,
- Shaheen Kabir,
- David A. Quigley,
- Eric J. Small,
- Alan Ashworth,
- Felix Y. Feng,
- Luke A. Gilbert
Affiliations
- Rajdeep Das
- Department of Radiation Oncology, University of California, San Francisco
- Martin Sjöström
- Department of Radiation Oncology, University of California, San Francisco
- Raunak Shrestha
- Department of Radiation Oncology, University of California, San Francisco
- Christopher Yogodzinski
- Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco
- Emily A. Egusa
- Department of Radiation Oncology, University of California, San Francisco
- Lisa N. Chesner
- Department of Radiation Oncology, University of California, San Francisco
- William S. Chen
- Department of Radiation Oncology, University of California, San Francisco
- Jonathan Chou
- Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco
- Donna K. Dang
- Department of Radiation Oncology, University of California, San Francisco
- Jason T. Swinderman
- Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco
- Alex Ge
- Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco
- Junjie T. Hua
- Department of Radiation Oncology, University of California, San Francisco
- Shaheen Kabir
- Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco
- David A. Quigley
- Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco
- Eric J. Small
- Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco
- Alan Ashworth
- Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco
- Felix Y. Feng
- Department of Radiation Oncology, University of California, San Francisco
- Luke A. Gilbert
- Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco
- DOI
- https://doi.org/10.1038/s41467-021-24919-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
It is hypothesized that there are a number of tumor specific driver genes for metastatic prostate cancer. Here, the authors perform genome-wide CRISPRi screens and integrate these data with metastatic prostate cancer functional and clinical genomics data to show that KIF4A and WDR62 drive aggressive prostate cancer phenotypes.
