Nature Communications (Mar 2021)
Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages
- Jennifer K. Dowling,
- Remsha Afzal,
- Linden J. Gearing,
- Mariana P. Cervantes-Silva,
- Stephanie Annett,
- Gavin M. Davis,
- Chiara De Santi,
- Nadine Assmann,
- Katja Dettmer,
- Daniel J. Gough,
- Glenn R. Bantug,
- Fidinny I. Hamid,
- Frances K. Nally,
- Conor P. Duffy,
- Aoife L. Gorman,
- Alex M. Liddicoat,
- Ed C. Lavelle,
- Christoph Hess,
- Peter J. Oefner,
- David K. Finlay,
- Gavin P. Davey,
- Tracy Robson,
- Annie M. Curtis,
- Paul J. Hertzog,
- Bryan R. G. Williams,
- Claire E. McCoy
Affiliations
- Jennifer K. Dowling
- School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland
- Remsha Afzal
- School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland
- Linden J. Gearing
- Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research
- Mariana P. Cervantes-Silva
- School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland
- Stephanie Annett
- School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland
- Gavin M. Davis
- School of Biochemistry and Immunology, Trinity College Dublin
- Chiara De Santi
- School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland
- Nadine Assmann
- School of Biochemistry and Immunology, Trinity College Dublin
- Katja Dettmer
- Institute of Functional Genomics, University of Regensburg
- Daniel J. Gough
- Department of Molecular and Translational Science, Monash University
- Glenn R. Bantug
- Immunobiology Laboratory, Department of Biomedicine, University Hospital Basel
- Fidinny I. Hamid
- Department of Molecular and Translational Science, Monash University
- Frances K. Nally
- School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland
- Conor P. Duffy
- School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland
- Aoife L. Gorman
- School of Biochemistry and Immunology, Trinity College Dublin
- Alex M. Liddicoat
- School of Biochemistry and Immunology, Trinity College Dublin
- Ed C. Lavelle
- School of Biochemistry and Immunology, Trinity College Dublin
- Christoph Hess
- Immunobiology Laboratory, Department of Biomedicine, University Hospital Basel
- Peter J. Oefner
- Institute of Functional Genomics, University of Regensburg
- David K. Finlay
- School of Biochemistry and Immunology, Trinity College Dublin
- Gavin P. Davey
- School of Biochemistry and Immunology, Trinity College Dublin
- Tracy Robson
- School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland
- Annie M. Curtis
- School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland
- Paul J. Hertzog
- Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research
- Bryan R. G. Williams
- Department of Molecular and Translational Science, Monash University
- Claire E. McCoy
- School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland
- DOI
- https://doi.org/10.1038/s41467-021-21617-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
IL-10 can limit inflammation in part by inhibiting miR-155. Here the authors show how this axis induces mitochondrial arginase-2 to alter the mitochondrial dynamics and bioenergetics of macrophages and make these cells less pro-inflammatory.
