Nuclear export and translation of circular repeat-containing intronic RNA in C9ORF72-ALS/FTD

Shaopeng Wang; Malgorzata J. Latallo; Zhe Zhang; Bo Huang; Dmitriy G. Bobrovnikov; Daoyuan Dong; Nathan M. Livingston; Wilson Tjoeng; Lindsey R. Hayes; Jeffrey D. Rothstein; Lyle W. Ostrow; Bin Wu; Shuying Sun

doi:10.1038/s41467-021-25082-9

Nature Communications (Aug 2021)

Nuclear export and translation of circular repeat-containing intronic RNA in C9ORF72-ALS/FTD

Shaopeng Wang,
Malgorzata J. Latallo,
Zhe Zhang,
Bo Huang,
Dmitriy G. Bobrovnikov,
Daoyuan Dong,
Nathan M. Livingston,
Wilson Tjoeng,
Lindsey R. Hayes,
Jeffrey D. Rothstein,
Lyle W. Ostrow,
Bin Wu,
Shuying Sun

Affiliations

Shaopeng Wang: Department of Pathology, Johns Hopkins University School of Medicine
Malgorzata J. Latallo: Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine
Zhe Zhang: Department of Pathology, Johns Hopkins University School of Medicine
Bo Huang: Department of Pathology, Johns Hopkins University School of Medicine
Dmitriy G. Bobrovnikov: Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine
Daoyuan Dong: Department of Pathology, Johns Hopkins University School of Medicine
Nathan M. Livingston: Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine
Wilson Tjoeng: Department of Pathology, Johns Hopkins University School of Medicine
Lindsey R. Hayes: Brain Science Institute, Johns Hopkins University School of Medicine
Jeffrey D. Rothstein: Brain Science Institute, Johns Hopkins University School of Medicine
Lyle W. Ostrow: Department of Neurology, Johns Hopkins University School of Medicine
Bin Wu: Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine
Shuying Sun: Department of Pathology, Johns Hopkins University School of Medicine

DOI: https://doi.org/10.1038/s41467-021-25082-9
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

Read online

Hexanucleotide repeat expansion in the intron 1 of the C9ORF72 gene can cause amyotrophic lateral sclerosis (ALS) and frontal temporal dementia (FTD). Here the authors use single molecule imaging to show nuclear export and translation of circular repeat-containing C9ORF72 intronic RNA.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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