PLoS ONE (Jan 2023)

Early pregnancy cardio metabolic risk factors and the prevalence of metabolic syndrome 10 years after the first pregnancy.

  • Prabha H Andraweera,
  • Michelle D Plummer,
  • Amy Garrett,
  • Shalem Leemaqz,
  • Melanie R Wittwer,
  • Emily Aldridge,
  • Maleesa M Pathirana,
  • Gus A Dekker,
  • Claire T Roberts,
  • Margaret A Arstall

DOI
https://doi.org/10.1371/journal.pone.0280451
Journal volume & issue
Vol. 18, no. 1
p. e0280451

Abstract

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BackgroundWe aimed to compare risk factors for CVD 10 years postpartum among women who had ≥ 1 compared to no cardio metabolic risk factor in early first pregnancy.MethodsWomen of the SCOPE (Screening fOr Pregnancy Endpoints) study from Adelaide, South Australia were invited to participate in a cardiovascular risk assessment 10 years after the delivery of the first child. Data from 141 women who completed all the assessments are included in the analyses.ResultCompared to women who did not have any cardio metabolic risk factor at 15 ± 1 weeks' gestation during the first pregnancy, those who had ≥ 1 risk factor were 5.5 times more likely to have metabolic syndrome 10 years postpartum (aOR = 5.5, 95% CI 1.8-17.3, p = 0.004). Women who had ≥ 1cardio metabolic risk factor during the first pregnancy were more likely to be obese (p = 0.001), have high total cholesterol levels (p ConclusionCardio metabolic risk factors at the booking visit in the first pregnancy may be useful in identifying young women at risk of future CVD.