A CpG island-encoded mechanism protects genes from premature transcription termination

Amy L. Hughes; Aleksander T. Szczurek; Jessica R. Kelley; Anna Lastuvkova; Anne H. Turberfield; Emilia Dimitrova; Neil P. Blackledge; Robert J. Klose

doi:10.1038/s41467-023-36236-2

Nature Communications (Feb 2023)

A CpG island-encoded mechanism protects genes from premature transcription termination

Amy L. Hughes,
Aleksander T. Szczurek,
Jessica R. Kelley,
Anna Lastuvkova,
Anne H. Turberfield,
Emilia Dimitrova,
Neil P. Blackledge,
Robert J. Klose

Affiliations

Amy L. Hughes: Department of Biochemistry, University of Oxford
Aleksander T. Szczurek: Department of Biochemistry, University of Oxford
Jessica R. Kelley: Department of Biochemistry, University of Oxford
Anna Lastuvkova: Department of Biochemistry, University of Oxford
Anne H. Turberfield: Department of Biochemistry, University of Oxford
Emilia Dimitrova: Department of Biochemistry, University of Oxford
Neil P. Blackledge: Department of Biochemistry, University of Oxford
Robert J. Klose: Department of Biochemistry, University of Oxford

DOI: https://doi.org/10.1038/s41467-023-36236-2
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 19

Abstract

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Here the authors discover that SET1 complexes function as transcription anti-termination factors that bind to CpG islands and protect low to moderately transcribed genes from the pervasive termination activity of the ZC3H4 complex.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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