Opposite physiological and pathological mTORC1-mediated roles of the CB1 receptor in regulating renal tubular function

Liad Hinden; Majdoleen Ahmad; Sharleen Hamad; Alina Nemirovski; Gergő Szanda; Sandra Glasmacher; Aviram Kogot-Levin; Rinat Abramovitch; Bernard Thorens; Jürg Gertsch; Gil Leibowitz; Joseph Tam

doi:10.1038/s41467-022-29124-8

Nature Communications (Apr 2022)

Opposite physiological and pathological mTORC1-mediated roles of the CB1 receptor in regulating renal tubular function

Liad Hinden,
Majdoleen Ahmad,
Sharleen Hamad,
Alina Nemirovski,
Gergő Szanda,
Sandra Glasmacher,
Aviram Kogot-Levin,
Rinat Abramovitch,
Bernard Thorens,
Jürg Gertsch,
Gil Leibowitz,
Joseph Tam

Affiliations

Liad Hinden: Obesity and Metabolism Laboratory, The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem
Majdoleen Ahmad: Obesity and Metabolism Laboratory, The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem
Sharleen Hamad: Obesity and Metabolism Laboratory, The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem
Alina Nemirovski: Obesity and Metabolism Laboratory, The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem
Gergő Szanda: Department of Physiology, Semmelweis University
Sandra Glasmacher: Institute of Biochemistry and Molecular Medicine, University of Bern
Aviram Kogot-Levin: Diabetes Unit and Endocrine Service, Hadassah-Hebrew University Medical Center
Rinat Abramovitch: The Wohl Institute for Translational Medicine, Hadassah-Hebrew University Medical Center
Bernard Thorens: Center for Integrative Genomics, University of Lausanne
Jürg Gertsch: Institute of Biochemistry and Molecular Medicine, University of Bern
Gil Leibowitz: Diabetes Unit and Endocrine Service, Hadassah-Hebrew University Medical Center
Joseph Tam: Obesity and Metabolism Laboratory, The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem

DOI: https://doi.org/10.1038/s41467-022-29124-8
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 18

Abstract

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Renal proximal tubules modulate whole-body homeostasis by sensing various nutrients. Here the authors describe the existence and importance of a unique CB1/mTORC1/GLUT2 signaling axis in regulating nutrient homeostasis in healthy and diseased kidney.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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