AIP limits neurotransmitter release by inhibiting calcium bursts from the ryanodine receptor

Bojun Chen; Ping Liu; Edward J. Hujber; Yan Li; Erik M. Jorgensen; Zhao-Wen Wang

doi:10.1038/s41467-017-01704-z

Nature Communications (Nov 2017)

AIP limits neurotransmitter release by inhibiting calcium bursts from the ryanodine receptor

Bojun Chen,
Ping Liu,
Edward J. Hujber,
Yan Li,
Erik M. Jorgensen,
Zhao-Wen Wang

Affiliations

Bojun Chen: Department of Neuroscience, University of Connecticut Health Center
Ping Liu: Department of Neuroscience, University of Connecticut Health Center
Edward J. Hujber: Department of Biology, University of Utah
Yan Li: Department of Neuroscience, University of Connecticut Health Center
Erik M. Jorgensen: Department of Biology, University of Utah
Zhao-Wen Wang: Department of Neuroscience, University of Connecticut Health Center

DOI: https://doi.org/10.1038/s41467-017-01704-z
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

Read online

In this work the authors show that AIP (aryl hydrocarbon receptor-interacting protein), a gene frequently mutated in association with pituitary tumors, regulates neurotransmitter release by inhibiting calcium release from ryanodine receptors.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal