Lantern-shaped flexible RNA origami for Smad4 mRNA delivery and growth suppression of colorectal cancer

Muren Hu; Chang Feng; Qianqin Yuan; Chenbin Liu; Bujun Ge; Fenyong Sun; Xiaoli Zhu

doi:10.1038/s41467-023-37020-y

Nature Communications (Mar 2023)

Lantern-shaped flexible RNA origami for Smad4 mRNA delivery and growth suppression of colorectal cancer

Muren Hu,
Chang Feng,
Qianqin Yuan,
Chenbin Liu,
Bujun Ge,
Fenyong Sun,
Xiaoli Zhu

Affiliations

Muren Hu: Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University
Chang Feng: Center for Molecular Recognition and Biosensing, School of Life Sciences, Shanghai University
Qianqin Yuan: Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University
Chenbin Liu: Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University
Bujun Ge: Department of General Surgery, Tongji Hospital, School of Medicine, Tongji University
Fenyong Sun: Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University
Xiaoli Zhu: Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University

DOI: https://doi.org/10.1038/s41467-023-37020-y
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 15

Abstract

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mRNA delivery has shown great potential in the treatment of various diseases. Here, the authors develop a lantern-shaped flexible origami for nanolization of single mRNA molecules and demonstrate efficient delivery of Smad4 mRNA, achieving suppression of colorectal cancer tumour growth.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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