Nanoscale kinetic segregation of TCR and CD45 in engaged microvilli facilitates early T cell activation

Yair Razvag; Yair Neve-Oz; Julia Sajman; Meital Reches; Eilon Sherman

doi:10.1038/s41467-018-03127-w

Nature Communications (Feb 2018)

Nanoscale kinetic segregation of TCR and CD45 in engaged microvilli facilitates early T cell activation

Yair Razvag,
Yair Neve-Oz,
Julia Sajman,
Meital Reches,
Eilon Sherman

Affiliations

Yair Razvag: Racah Institute of Physics, The Hebrew University
Yair Neve-Oz: Racah Institute of Physics, The Hebrew University
Julia Sajman: Racah Institute of Physics, The Hebrew University
Meital Reches: Institute of Chemistry, The Hebrew University
Eilon Sherman: Racah Institute of Physics, The Hebrew University

DOI: https://doi.org/10.1038/s41467-018-03127-w
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 17

Abstract

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T cell activation is critically controlled by T cell receptor (TCR) signalling. Here the authors show, using live cell imaging, atomic force microscopy and modelling simulation, a prompt separation of TCR and CD45 that negatively correlates with TCR activation, supporting a refined kinetic segregation model of TCR signalling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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