Extrahepatic causes of morbidity and mortality of liver recipients in the long-term posttransplantation period

Abstract

Nowadays, the one-year survival rate of liver transplant recipients is 80-90 %. In the long term after surgery, there are increased risks of death compared with the general population. At the same time, in the structure of death of recipients, extrahepatic causes prevail over graft pathology. Cancers, cardiovascular diseases, infections, metabolic disorders, and kidney disease are key factors that negatively affect long-term outcomes of transplants. The article provides an overview and summary of current data on the prevalence, structure and prognostic value of various types’ of late post-transplant extrahepatic pathology in liver transplant recipients.

Keywords

• liver transplantation
• long-term outcomes
• cancer
• cardiovascular disease
• infections
• metabolic disorders
• kidney diseases