ABCA1 is an extracellular phospholipid translocase

Jere P. Segrest; Chongren Tang; Hyun D. Song; Martin K. Jones; W. Sean Davidson; Stephen G. Aller; Jay W. Heinecke

doi:10.1038/s41467-022-32437-3

Nature Communications (Aug 2022)

ABCA1 is an extracellular phospholipid translocase

Jere P. Segrest,
Chongren Tang,
Hyun D. Song,
Martin K. Jones,
W. Sean Davidson,
Stephen G. Aller,
Jay W. Heinecke

Affiliations

Jere P. Segrest: Department of Medicine, Vanderbilt University Medical Center
Chongren Tang: Department of Medicine, University of Washington
Hyun D. Song: Department of Medicine, Vanderbilt University Medical Center
Martin K. Jones: Department of Medicine, Vanderbilt University Medical Center
W. Sean Davidson: Department of Pathology and Laboratory Medicine, University of Cincinnati
Stephen G. Aller: Department of Pharmacology & Toxicology, University of Alabama at Birmingham
Jay W. Heinecke: Department of Medicine, University of Washington

DOI: https://doi.org/10.1038/s41467-022-32437-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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ATP-binding cassette transporter A1 (ABCA1) drives phospholipid (PL) from the plasma membrane into extracellular apolipoprotein A-I, for the production of high density lipoprotein (HDL). Here, the authors use simulations to assess the mechanism of ABCA1 function and show that ABCA1 extracts lipid from the outer face of the plasma membrane.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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