Is Melanoma Progression Affected by Thyroid Diseases?

Salvatore Ulisse; Enke Baldini; Daniele Pironi; Federica Gagliardi; Domenico Tripodi; Augusto Lauro; Sabino Carbotta; Danilo Tarroni; Matteo D’Armiento; Aldo Morrone; Flavio Forte; Flaminia Frattaroli; Severino Persechino; Teresa Odorisio; Vito D’Andrea; Eleonora Lori; Salvatore Sorrenti

doi:10.3390/ijms231710036

International Journal of Molecular Sciences (Sep 2022)

Is Melanoma Progression Affected by Thyroid Diseases?

Salvatore Ulisse,
Enke Baldini,
Daniele Pironi,
Federica Gagliardi,
Domenico Tripodi,
Augusto Lauro,
Sabino Carbotta,
Danilo Tarroni,
Matteo D’Armiento,
Aldo Morrone,
Flavio Forte,
Flaminia Frattaroli,
Severino Persechino,
Teresa Odorisio,
Vito D’Andrea,
Eleonora Lori,
Salvatore Sorrenti

Affiliations

Salvatore Ulisse: Department of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, Italy
Enke Baldini: Department of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, Italy
Daniele Pironi: Department of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, Italy
Federica Gagliardi: Department of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, Italy
Domenico Tripodi: Department of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, Italy
Augusto Lauro: Department of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, Italy
Sabino Carbotta: Department of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, Italy
Danilo Tarroni: Department of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, Italy
Matteo D’Armiento: Scientific Direction, IRCCS San Gallicano Dermatological Institute, 00144 Rome, Italy
Aldo Morrone: Scientific Direction, IRCCS San Gallicano Dermatological Institute, 00144 Rome, Italy
Flavio Forte: Urology Department, M.G. Vannini Hospital, 00177 Rome, Italy
Flaminia Frattaroli: Department of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, Italy
Severino Persechino: Department of Neurosciences, Mental Health and Sensory Organs, “Sapienza” University of Rome, 00161 Rome, Italy
Teresa Odorisio: Laboratory of Molecular and Cell Biology, Istituto Dermopatico dell’Immacolata, IDI-IRCCS, 00167 Rome, Italy
Vito D’Andrea: Department of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, Italy
Eleonora Lori: Department of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, Italy
Salvatore Sorrenti: Department of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, Italy

DOI: https://doi.org/10.3390/ijms231710036
Journal volume & issue: Vol. 23, no. 17
p. 10036

Abstract

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Clinical and epidemiological evidence indicate a relationship between thyroid diseases and melanoma. In particular, the hypothyroidism condition appears to promote melanoma spread, which suggests a protective role of thyroid hormones against disease progression. In addition, experimental data suggest that, in addition to thyroid hormones, other hormonal players of the hypothalamic–pituitary–thyroid (HPT) axis, namely the thyrotropin releasing hormone and the thyrotropin, are likely to affect melanoma cells behavior. This information warrants further clinical and experimental studies in order to build a precise pattern of action of the HPT hormones on melanoma cells. An improved knowledge of the involved molecular mechanism(s) could lead to a better and possibly personalized clinical management of these patients.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

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