The Antiallodynic Action of Pregabalin May Depend on the Suppression of Spinal Neuronal Hyperexcitability in Rats with Spared Nerve Injury

Lei Ding; Jie Cai; Xiang-Yang Guo; Xiu-Li Meng; Guo-Gang Xing

doi:10.1155/2014/623830

Pain Research and Management (Jan 2014)

The Antiallodynic Action of Pregabalin May Depend on the Suppression of Spinal Neuronal Hyperexcitability in Rats with Spared Nerve Injury

Lei Ding,
Jie Cai,
Xiang-Yang Guo,
Xiu-Li Meng,
Guo-Gang Xing

Affiliations

Lei Ding: Department of Anesthesiology, Peking University Third Hospital, China
Jie Cai: Neuroscience Research Institute and Department of Neurobiology, Peking University, Key Laboratory for Neuroscience of the Ministry of Education and the Ministry of Public Health, Beijing, China
Xiang-Yang Guo: Department of Anesthesiology, Peking University Third Hospital, China
Xiu-Li Meng: Department of Anesthesiology, Peking University Third Hospital, China
Guo-Gang Xing: Neuroscience Research Institute and Department of Neurobiology, Peking University, Key Laboratory for Neuroscience of the Ministry of Education and the Ministry of Public Health, Beijing, China

DOI: https://doi.org/10.1155/2014/623830
Journal volume & issue: Vol. 19, no. 4
pp. 205 – 211

Abstract

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BACKGROUND: Pregabalin (PGB) is a novel antiepileptic drug and is also used as a first-line medication for the treatment of neuropathic pain. However, the mechanisms of its analgesic effects remain largely unknown.

Published in Pain Research and Management

ISSN: 1203-6765 (Print); 1918-1523 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Medicine (General)
Website: https://onlinelibrary.wiley.com/journal/7040

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