mSphere (Apr 2021)

Term Human Placental Trophoblasts Express SARS-CoV-2 Entry Factors ACE2, TMPRSS2, and Furin

  • Yingshi Ouyang,
  • Tarique Bagalkot,
  • Wendy Fitzgerald,
  • Elena Sadovsky,
  • Tianjiao Chu,
  • Ana Martínez-Marchal,
  • Miguel Brieño-Enríquez,
  • Emily J. Su,
  • Leonid Margolis,
  • Alexander Sorkin,
  • Yoel Sadovsky

DOI
https://doi.org/10.1128/mSphere.00250-21
Journal volume & issue
Vol. 6, no. 2

Abstract

Read online

Pregnant women worldwide have been affected by COVID-19. As the virus is commonly spread to various organs via the bloodstream and because human placental trophoblasts are directly bathed in maternal blood, feto-placental infection by SARS-CoV-2 seems likely.