Term Human Placental Trophoblasts Express SARS-CoV-2 Entry Factors ACE2, TMPRSS2, and Furin

Yingshi Ouyang; Tarique Bagalkot; Wendy Fitzgerald; Elena Sadovsky; Tianjiao Chu; Ana Martínez-Marchal; Miguel Brieño-Enríquez; Emily J. Su; Leonid Margolis; Alexander Sorkin; Yoel Sadovsky

doi:10.1128/mSphere.00250-21

mSphere (Apr 2021)

Term Human Placental Trophoblasts Express SARS-CoV-2 Entry Factors ACE2, TMPRSS2, and Furin

Yingshi Ouyang,
Tarique Bagalkot,
Wendy Fitzgerald,
Elena Sadovsky,
Tianjiao Chu,
Ana Martínez-Marchal,
Miguel Brieño-Enríquez,
Emily J. Su,
Leonid Margolis,
Alexander Sorkin,
Yoel Sadovsky

Affiliations

Yingshi Ouyang: ORCiD; Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Tarique Bagalkot: ORCiD; Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Wendy Fitzgerald: ORCiD; Section on Intercellular Interaction, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
Elena Sadovsky: ORCiD; Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Tianjiao Chu: ORCiD; Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Ana Martínez-Marchal: ORCiD; Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Miguel Brieño-Enríquez: ORCiD; Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Emily J. Su: ORCiD; Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, Colorado, USA
Leonid Margolis: ORCiD; Section on Intercellular Interaction, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
Alexander Sorkin: ORCiD; Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Yoel Sadovsky: ORCiD; Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

DOI: https://doi.org/10.1128/mSphere.00250-21
Journal volume & issue: Vol. 6, no. 2

Abstract

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Pregnant women worldwide have been affected by COVID-19. As the virus is commonly spread to various organs via the bloodstream and because human placental trophoblasts are directly bathed in maternal blood, feto-placental infection by SARS-CoV-2 seems likely.

Published in mSphere

ISSN: 2379-5042 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/msphere

About the journal