Proteomics of resistance to Notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signatures

Giulia Franciosa; Jos G. A. Smits; Sonia Minuzzo; Ana Martinez-Val; Stefano Indraccolo; Jesper V. Olsen

doi:10.1038/s41467-021-22787-9

Nature Communications (May 2021)

Proteomics of resistance to Notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signatures

Giulia Franciosa,
Jos G. A. Smits,
Sonia Minuzzo,
Ana Martinez-Val,
Stefano Indraccolo,
Jesper V. Olsen

Affiliations

Giulia Franciosa: Proteomics Program, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen
Jos G. A. Smits: Proteomics Program, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen
Sonia Minuzzo: Department of Surgery, Oncology and Gastroenterology, University of Padova
Ana Martinez-Val: Proteomics Program, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen
Stefano Indraccolo: Department of Surgery, Oncology and Gastroenterology, University of Padova
Jesper V. Olsen: Proteomics Program, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen

DOI: https://doi.org/10.1038/s41467-021-22787-9
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 19

Abstract

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NOTCH1 is a driver of T-cell acute lymphoblastic leukemia that can be inhibited by γ-secretase inhibitors (GSIs), but their clinical efficacy is limited. Here, the authors compare the phosphoproteomes of GSI resistant and sensitive models, and identify potential kinase targets to overcome GSI resistance.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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