Anti-Inflammatory and Antioxidant Potentials of Merremia hederacea (Burm.Fil) Leaves

Abstract

Background and Aim: This study aimed to identify the existence of phytochemical compounds and evaluate the in-vitro antioxidant and anti-inflammatory potentials of the leaves extract of Merremia hederacea which is commonly known as ivy woodrose. Materials and Methods: The antioxidant potency was measured using DPPH radical scavenging method and reducing power capacity followed by calculating phenol and flavonoid contents. To test the anti-inflammatory effect, the protein-denaturation method was applied. Results: Based on the DPPH scavenging activity, the IC50 value of the extract was determined to be 416.977. The amounts of phenolic content and flavonoids as well as the reducing power of this extract were found satisfactory. The extract remarkably hindered the denaturation of protein in the anti-inflammatory activity test with a maximum of 68.86% inhibition at 500 μg/mL concentration. Conclusion: The results indicate that M. hederacea leaves have favorable antioxidant and anti-inflammatory potencies; hence, this plant can be an effective source of new potent drugs

Keywords

• merremia hederacea, plant extracts, phytochemicals, antioxidants, anti-inflammatory