Aerosol and Contact Transmission Following Intranasal Infection of Mice with Japanese Encephalitis Virus

Chunxia Chai; Rachel Palinski; Yixuan Xu; Qiao Wang; Sanjie Cao; Yi Geng; Qin Zhao; Yiping Wen; Xiaobo Huang; Qiguai Yan; Xiaoping Ma; Xintian Wen; Yong Huang; Xinfeng Han; Wenjun Ma; Rui Wu

doi:10.3390/v11010087

Viruses (Jan 2019)

Aerosol and Contact Transmission Following Intranasal Infection of Mice with Japanese Encephalitis Virus

Chunxia Chai,
Rachel Palinski,
Yixuan Xu,
Qiao Wang,
Sanjie Cao,
Yi Geng,
Qin Zhao,
Yiping Wen,
Xiaobo Huang,
Qiguai Yan,
Xiaoping Ma,
Xintian Wen,
Yong Huang,
Xinfeng Han,
Wenjun Ma,
Rui Wu

Affiliations

Chunxia Chai: Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Rachel Palinski: Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
Yixuan Xu: Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Qiao Wang: Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Sanjie Cao: Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Yi Geng: College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Qin Zhao: Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Yiping Wen: Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Xiaobo Huang: Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Qiguai Yan: Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Xiaoping Ma: Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Xintian Wen: Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Yong Huang: Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Xinfeng Han: Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Wenjun Ma: Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
Rui Wu: Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China

DOI: https://doi.org/10.3390/v11010087
Journal volume & issue: Vol. 11, no. 1
p. 87

Abstract

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The Japanese encephalitis virus (JEV), a causative agent of severe viral encephalitis in humans, has a biological cycle fluctuating between transmission in mosquitoes and avian species and amplification in pigs. Contact transmission of JEV was recently shown in pigs in the absence of arthropod vectors. Here, we show JEV transmission between infected and contact mice and further demonstrate that JEV transmission occurs between animals via aerosols, as both viral RNA and infectious JEV were detected in direct contact- and aerosol-exposed contact animals. The results of this study change our understanding of JEV transmission in densely populated regions and may help to explain JEV outbreaks without the presence of arthropod vectors.

Published in Viruses

ISSN: 1999-4915 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.mdpi.com/journal/viruses

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