Expression of the stem cell marker CD133 is related to tumor development in colorectal carcinogenesis

Shinsuke Kazama; Junko Kishikawa; Tomomichi Kiyomatsu; Kazushige Kawai; Hiroaki Nozawa; Soichiro Ishihara; Toshiaki Watanabe

Asian Journal of Surgery (May 2018)

Expression of the stem cell marker CD133 is related to tumor development in colorectal carcinogenesis

Shinsuke Kazama,
Junko Kishikawa,
Tomomichi Kiyomatsu,
Kazushige Kawai,
Hiroaki Nozawa,
Soichiro Ishihara,
Toshiaki Watanabe

Affiliations

Shinsuke Kazama: Corresponding author. Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.; Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan
Junko Kishikawa: Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan
Tomomichi Kiyomatsu: Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan
Kazushige Kawai: Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan
Hiroaki Nozawa: Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan
Soichiro Ishihara: Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan
Toshiaki Watanabe: Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

Journal volume & issue: Vol. 41, no. 3
pp. 274 – 278

Abstract

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Summary: Background/Objective: CD133 is currently considered the most robust surface marker for colorectal cancer stem cells. Two meta-analysis reports have suggested that CD133 expression is significantly associated with shorter survival, and CD133 may play an important role in the progression of colorectal cancer. However, the role of CD133 in colorectal adenoma has not been fully elucidated. Methods: We used immunohistochemistry to evaluate CD133 expression in 200 endoscopically resected colorectal polyps from 200 patients and 20 normal mucosae between January 1993 and December 1996. Results: CD133 staining was positive in 17.9% of the colorectal adenomas. Moreover, CD133 expression was associated with differentiation status (p = 0.003) and tumor size (p = 0.03). Conclusion: CD133 might play an important role in tumor development. Keywords: CD133, colorectal adenoma, immunohistochemistry

Published in Asian Journal of Surgery

ISSN: 1015-9584 (Print)
Publisher: Elsevier
Country of publisher: Hong Kong
LCC subjects: Medicine: Surgery
Website: http://www.journals.elsevier.com/asian-journal-of-surgery/

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