SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia

Chen Kang; Litao Xie; Susheel K. Gunasekar; Anil Mishra; Yanhui Zhang; Saachi Pai; Yiwen Gao; Ashutosh Kumar; Andrew W. Norris; Samuel B. Stephens; Rajan Sah

doi:10.1038/s41467-017-02664-0

Nature Communications (Jan 2018)

SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia

Chen Kang,
Litao Xie,
Susheel K. Gunasekar,
Anil Mishra,
Yanhui Zhang,
Saachi Pai,
Yiwen Gao,
Ashutosh Kumar,
Andrew W. Norris,
Samuel B. Stephens,
Rajan Sah

Affiliations

Chen Kang: Department of Internal Medicine, Division of Cardiovascular Medicine, University of Iowa, Carver College of Medicine
Litao Xie: Department of Internal Medicine, Division of Cardiovascular Medicine, University of Iowa, Carver College of Medicine
Susheel K. Gunasekar: Department of Internal Medicine, Division of Cardiovascular Medicine, University of Iowa, Carver College of Medicine
Anil Mishra: Department of Internal Medicine, Division of Cardiovascular Medicine, University of Iowa, Carver College of Medicine
Yanhui Zhang: Department of Internal Medicine, Division of Cardiovascular Medicine, University of Iowa, Carver College of Medicine
Saachi Pai: Department of Internal Medicine, Division of Cardiovascular Medicine, University of Iowa, Carver College of Medicine
Yiwen Gao: Department of Internal Medicine, Division of Cardiovascular Medicine, University of Iowa, Carver College of Medicine
Ashutosh Kumar: Department of Internal Medicine, Division of Cardiovascular Medicine, University of Iowa, Carver College of Medicine
Andrew W. Norris: Department of Pediatrics, University of Iowa, Carver College of Medicine
Samuel B. Stephens: Department of Internal Medicine, Division of Cardiovascular Medicine, University of Iowa, Carver College of Medicine
Rajan Sah: Department of Internal Medicine, Division of Cardiovascular Medicine, University of Iowa, Carver College of Medicine

DOI: https://doi.org/10.1038/s41467-017-02664-0
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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Insulin secretion by β-cells is stimulated by glucose and is dependent on the induction of β-cell membrane depolarization, mainly driven by the closure of KATP channels, which in turn promotes voltage-gated Ca2+ channel opening. Here Kang et al. show that the volume-regulated anion channel, SWELL1, is involved in glucose-stimulated calcium increase and insulin secretion.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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